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Role of cellular defects in glucose transport and insulin signaling pathway in development of insulin resistance and type 2 diabetes / Wessam Mohammad Samy AbdAssalam ; Suppervised Randa Mahmoud Al Harizy , Khalid Farag Kasem

By: Contributor(s): Language: Eng Publication details: Cairo : Wessam Mohammad Samy AbdAssalam , 2006Description: 114P ; 30cmSubject(s): Online resources: Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty Of Medicine - Department Of Internal Medicine Summary: In skeletal muscle , insulin resistance may be caused by defects in glucose transport , which may be in the translocation , fusion , or exposure and activation of GLUT - 4 glucose transporters which may be due to defects in intracellular signalingThese defects may be inherent or may be due to circulating or paracrine factors such as hyperglycemia (glucose toxicity) or increased serum free fatty acids or TNF - Drugs such as metformin and thiazolidinediones improve insulin sensitivitythe impairment in insulin - stimulated glucose transport can be bypassed by other stimuli , such as exercise and hypoxia , which increase GLUT - 4 translocation and lead to the treatment of insulin resistance ,
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2006.We.R. (Browse shelf(Opens below)) Not for loan 01010110045640000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.18.M.Sc.2006.We.R. (Browse shelf(Opens below)) 45640.CD Not for loan 01020110045640000

Thesis (M.Sc.) - Cairo University - Faculty Of Medicine - Department Of Internal Medicine

In skeletal muscle , insulin resistance may be caused by defects in glucose transport , which may be in the translocation , fusion , or exposure and activation of GLUT - 4 glucose transporters which may be due to defects in intracellular signalingThese defects may be inherent or may be due to circulating or paracrine factors such as hyperglycemia (glucose toxicity) or increased serum free fatty acids or TNF - Drugs such as metformin and thiazolidinediones improve insulin sensitivitythe impairment in insulin - stimulated glucose transport can be bypassed by other stimuli , such as exercise and hypoxia , which increase GLUT - 4 translocation and lead to the treatment of insulin resistance ,

Issued also as CD

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