Synthesis and biological evaluation of novel diaryl heterocycle derivatives with potential anticancer and phosphodiesterase {u2162} inhibitory activities / Marwa Saad Mohamed Hany ; Supervised Ashraf H. Abadi , Khaled A. Abouzid
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TextLanguage: English Publication details: Cairo : Marwa Saad Mohamed Hany , 2010Description: 106 Leaves : facsimiles ; 30cmOnline resources: Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: Milrinone is a 3-cyano-2-pyridone derivative that has been introduced for the treatment of CHF. Its mechanism of action involves inhibition of PDE3, leading to elevation of cAMP, increasing the entry of calcium ions into the cardiac tissues, and hence increasing the contractility of the cardiac muscle. Moreover, recent studies showed that PDE3 and other PDEs are over-expressed in malignant tumors and inhibition of such PDEs and consequent high levels of cAMP, or cGMP, or both may be associated with anticancer and apoptotic activities
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Thesis
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قاعة الثقاقات الاجنبية - الدور الثالث | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.34.M.Sc.2010.Ma.S (Browse shelf(Opens below)) | Not for loan | 01010110060260000 |
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry
Milrinone is a 3-cyano-2-pyridone derivative that has been introduced for the treatment of CHF. Its mechanism of action involves inhibition of PDE3, leading to elevation of cAMP, increasing the entry of calcium ions into the cardiac tissues, and hence increasing the contractility of the cardiac muscle. Moreover, recent studies showed that PDE3 and other PDEs are over-expressed in malignant tumors and inhibition of such PDEs and consequent high levels of cAMP, or cGMP, or both may be associated with anticancer and apoptotic activities
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