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Synthesis and pharmacological evaluation of 1-Benzyl and 1-Benzoyl melatonin analogs as ligands for melatonin receptors / Amal Mahmoud Yassin Mohsen ; Supervised Darius P. Zlotos

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Amal Mahmoud Yassin Mohsen , 2010Description: 84Leaves : charts , facsimiles ; 30cmOther title:
  • تشييد وتقييم بيولوجى ل ن 1 بنزايل و ن 1 بنزويل من مشتقات الميلاتونين كلجائن لمستقبلات الميلاتونين [Added title page title]
Online resources: Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: The neurohormone melatonin (MLT) exerts its diverse physiological actions mostly through activation of the two G-protein-coupled MT₁ and MT₂ receptors . An accurate characterization of MLT receptor-mediated functions requires MT₁ and MT₂ selective ligands . One of the most selective MT₂ antagonists up to date is the p - chlorobenzl substituted indole derivative UCM 454
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Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

The neurohormone melatonin (MLT) exerts its diverse physiological actions mostly through activation of the two G-protein-coupled MT₁ and MT₂ receptors . An accurate characterization of MLT receptor-mediated functions requires MT₁ and MT₂ selective ligands . One of the most selective MT₂ antagonists up to date is the p - chlorobenzl substituted indole derivative UCM 454

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