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Design and synthesis of novel tetrahydro Ý-carboline derivatives and their biological evaluation as phosphodiesterase 5 inhibitors and apoptotic agents / Shreen Mohamad Elnashar ; Supervised Ashraf H. Abadi , Nermin S. Ahmed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shreen Mohamad Elnashar , 2011Description: 91 Leaves : facsimiles ; 30cmOnline resources: Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: Recently, many studies and researches are carried out to study PDE5 and its inhibitors due to their promising therapeutic uses. PDE5 has been successfully targeted for treatment of male erectile dysfunction. The success of sildenafil (Viagra®), vardenafil (Levitra®) and tadalafil (Cialis®) in this regard has renewed interest in PDE5 as potential pharmacological targets
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Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

Recently, many studies and researches are carried out to study PDE5 and its inhibitors due to their promising therapeutic uses. PDE5 has been successfully targeted for treatment of male erectile dysfunction. The success of sildenafil (Viagra®), vardenafil (Levitra®) and tadalafil (Cialis®) in this regard has renewed interest in PDE5 as potential pharmacological targets

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