Modulating celecoxib activity towards phosphodiesterase 5 inhibition rather than cyclooxygenase inhibition and evaluating its correlation to anticancer activity / Amro Hefnawy Mohamed Hefnawy ; Supervised Ashraf H. Abadi

By:

Amro Hefnawy Mohamed Hefnawy

Contributor(s):

Ashraf Mustafa Kamal Hassan Abadi []

Material type: Text

TextLanguage: English Publication details: Cairo : Amro Hefnawy Mohamed Hefnawy , 2013Description: 95 Leaves : photographs ; 30cmOther title:

تحوير نشاط السيليكوكسيب باتجاه تثبيط الفوسفودايستراز ٥ بدلا من انزيمات الأكسدة الحلقية و ارتباط ذلك بالنشاط المضاد للسرطان [Added title page title]

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Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry Summary: Selective COX-2 inhibitors were introduced as safer alternatives to NSAIDs with less gastrointestinal side effects. Celecoxib, Rofecoxib and valdecoxib were the most widely used COX-2 inhibitors. Unfortunately, it was found that the use of selective COX-2 inhibitors is associated with increased cardiovascular risk. By 2011, celecoxib was the only selective COX-2 inhibitors to remain available in the market as it showed better cardiovascular safety

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Item type	Current library	Home library	Call number	Status	Barcode
Thesis	قاعة الثقاقات الاجنبية - الدور الثالث	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.34.M.Sc.2013.Am.M (Browse shelf(Opens below))	Not for loan	01010110063692000

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Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

Selective COX-2 inhibitors were introduced as safer alternatives to NSAIDs with less gastrointestinal side effects. Celecoxib, Rofecoxib and valdecoxib were the most widely used COX-2 inhibitors. Unfortunately, it was found that the use of selective COX-2 inhibitors is associated with increased cardiovascular risk. By 2011, celecoxib was the only selective COX-2 inhibitors to remain available in the market as it showed better cardiovascular safety

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