Methylene blue decreases brain mitochondrial ABAD levels protecting mitochondrial function / Aya Zakaria Gamal Eldin Rashed ; Supervised Reham Mahmoud Abdelkader , Nabila Hamdi

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Aya Zakaria Gamal Eldin Rashed

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Material type: Text

TextLanguage: English Publication details: Cairo : Aya Zakaria Gamal Eldin Rashed , 2013Description: 100 Leaves : charts , photographs ; 30cmOnline resources:

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Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmacology and Toxicology Summary: Methylene blue (MB) is lately being proposed to be effective in treating alzheimer's disease (AD). Phase 2 clinical trials reported improvements in cognitive functions of AD patients after MB treatment. However, the exact mechanism of action of MB is still controversial and needs further investigations. Recently, the mitochondrial enzyme amyloid binding alcohol dehydrogenase (ABAD) has been shown to bind AÝ inducing mitochondrial dysfunction, providing a direct relation between AÝ and mitochondrial dysfunction occurring in AD

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Item type	Current library	Home library	Call number	Status	Barcode
Thesis	قاعة الثقاقات الاجنبية - الدور الثالث	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.34.M.Sc.2013.Ay.M (Browse shelf(Opens below))	Not for loan	01010110063696000

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Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmacology and Toxicology

Methylene blue (MB) is lately being proposed to be effective in treating alzheimer's disease (AD). Phase 2 clinical trials reported improvements in cognitive functions of AD patients after MB treatment. However, the exact mechanism of action of MB is still controversial and needs further investigations. Recently, the mitochondrial enzyme amyloid binding alcohol dehydrogenase (ABAD) has been shown to bind AÝ inducing mitochondrial dysfunction, providing a direct relation between AÝ and mitochondrial dysfunction occurring in AD

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