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Synthesis of some novel pyrazolopyrimidine derivatives of biological interest / Walaa Ramadan Mahmoud ; Supervised Safinaz Elsayed Abbas , Enayat Ibrahim Ali , Fadi Mohsen Awadallah

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Walaa Ramadan Mahmoud , 2013Description: 138 P. ; 25cmOther title:
  • تشييد بعض المشتقات الجديدة من البيرازولوبيريميدين ذات الإهتمام البيولوجي [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: Pyrazolopyrimidine derivatives received considerable interest as they are associated with a wide range of biological activities. The present investigation pointed toward the antitumor and antimicrobial activities of some 4- substituted - 1- phenyl pyrazolo [3, 4- d] pyrimidines. The new compounds were designed to incorporate several structural features including: alicyclic moieties as 4- (4- un / substituted phenyl)piperidin - 1- yl / piperazin - 1- yl VIIIa - f, six membered heterocycles as 6- o x o- 4- (4-un/substituted phenyl) -1, 6- dihydropyrimidine - 5- carbonitriles Xa - f and XIIa - f via a sulfanyl linker or hydrazinyl spacer, respectively and five membered heterocycles as 4- (4- un / substituted benzylidene) imidazol - 5 (4H) - one XIa - f through an amino linker
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2013.Wa.S (Browse shelf(Opens below)) Not for loan 01010110063203000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.Ph.D.2013.Wa.S (Browse shelf(Opens below)) 63203.CD Not for loan 01020110063203000

Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

Pyrazolopyrimidine derivatives received considerable interest as they are associated with a wide range of biological activities. The present investigation pointed toward the antitumor and antimicrobial activities of some 4- substituted - 1- phenyl pyrazolo [3, 4- d] pyrimidines. The new compounds were designed to incorporate several structural features including: alicyclic moieties as 4- (4- un / substituted phenyl)piperidin - 1- yl / piperazin - 1- yl VIIIa - f, six membered heterocycles as 6- o x o- 4- (4-un/substituted phenyl) -1, 6- dihydropyrimidine - 5- carbonitriles Xa - f and XIIa - f via a sulfanyl linker or hydrazinyl spacer, respectively and five membered heterocycles as 4- (4- un / substituted benzylidene) imidazol - 5 (4H) - one XIa - f through an amino linker

Issued also as CD

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