Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry

Diabetic nephropathy is the most prevalent cause for end - stage renal disease in the united states and the western world. In this disease, tubular injury and progressive interstitial fibrosis contribute significantly to renal failure and predict progression to end-stage renal disease. In early diabetic renal injury, there is podocyte drop - out which is thought to cause glomerular proteinuria and subsequent diabetic glomerular injury. Different inflammatory molecules including pro - inflammatory cytokines have been proposed as critical factors in the development of microvascular diabetic complications including nephropathy

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