Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine- Department of Biochemistry and Chemistry of Nutrition

Osteoarthritis (OA) is a degenerative disease characterized by the progressive degradation of joint cartilage and is accompanied by secondary inflammation of synovial membranes. The present work was devoted to investigate some biochemical changes in knee joint and serum constituents resulting from MIA experimentally induced osteoarthritis in rats and to illustrate the effects of ginger or mushroom supplementation as well as hyaluronic acid treatment against these adverse changes. Forty-eight male rats were divided into eight groups, as a control, ginger, hyaluronic acid, mushroom, osteoarthritic, OA-ginger, OA-hyaluronic acid and OA-mushroom. Serum samples from all rats were used for estimation of total protein level, C - reactive protein, and interleukin-6 concentration. Knee joint tissues from all rats were used for analysis of reduced glutathione, glutathione peroxidase, malondialdehyde, catalase, superoxide dismutase, and total protein level

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