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Clinicopathological changes associated with gold nanoparticles{u2019} administration in healthy and tumor-induced hamsters / Omar Abdellatif Mahmoud Soliman ; Supervised Alaa Raafat Ahmed , Adel Khalil Ibrahim , Hazem Mohamed Saleh

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Omar Abdellatif Mahmoud Soliman , 2014Description: 104 P. : charts , facsimiles ; 25cmOther title:
  • التغيرات الباثولوجية الإكلينيكية المصاحبة لإعطاء جسيمات الذهب النانوية في الهامستر السليمة والمصابة بالأورام [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Clinical Pathology Summary: Toxicity of gold nanoparticles (GNPs) depends on their size, shape, dose, capping agent, surface chemistry, animal model used, frequency and duration of exposure, and route of administration. In the present study, we investigated the clinicopathological changes associated with administration of GNPs and anti-EGFR-GNPs in healthy and tumor-induced hamsters, respectively. Systemic repeated I/P injection of {u2248}18 nm naked GNPs (as verified by transmission electron microscope) at a dose of 30 ppb daily for 2 weeks induced macrocytosis, hypochromasia, leukocytosis, neutrophilia, mild lymphocytosis and monocytosis. Hepatic and renal function parameters remained unchanged in GNPs-treated hamsters when compared to control group
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.05.M.Sc.2014.Om.C (Browse shelf(Opens below)) Not for loan 01010110063759000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.05.M.Sc.2014.Om.C (Browse shelf(Opens below)) 63759.CD Not for loan 01020110063759000

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Clinical Pathology

Toxicity of gold nanoparticles (GNPs) depends on their size, shape, dose, capping agent, surface chemistry, animal model used, frequency and duration of exposure, and route of administration. In the present study, we investigated the clinicopathological changes associated with administration of GNPs and anti-EGFR-GNPs in healthy and tumor-induced hamsters, respectively. Systemic repeated I/P injection of {u2248}18 nm naked GNPs (as verified by transmission electron microscope) at a dose of 30 ppb daily for 2 weeks induced macrocytosis, hypochromasia, leukocytosis, neutrophilia, mild lymphocytosis and monocytosis. Hepatic and renal function parameters remained unchanged in GNPs-treated hamsters when compared to control group

Issued also as CD

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