Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Histology

The present work aimed to study the possible histological and immunohistochemical changes that occur due to ischemia reperfusion injury of rat's ovary and possible protective effect of vitamin c as antioxidants . Thirty five female rats were randomized into 7 groups. group 1: control, group 2: control given vitamin c for 2 weeks, group 3: ischemia only for4 hours , group 4: ischemia 4hours then reperfusion 1 hour group 5: ischemia 4hours then reperfusion two weeks, recovery group6: ischemia 4hours then vitamin c injected intra venous 50mg/kg then reperfusion 1 hour group 7: ischemia 4hours then vitamin c injected intra venous 50mg/kg than reperfusion 2week as recovery the animals were sacrificed after 5hours for groups 1,3,4,6 and 2 weeks for group 2,5, 7 from the start of the experiment. Specimens were fixed immediately in 10% buffered formalin for histological and immunohistochemical studies. Image analysis and statistical analysis of the obtained results were performed

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