Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology

Pharmacokinetics of lincomycin was studied following single i.v and oral administrations (20 mg / kg b.wt) in both control and gallimix (as acidifier) in medicated broiler chickens. Lincomycin serum concentration was determined by microbiological assay method. Following i.v. injection in group fed free acidifiers and acidifiers containing ration, lincomycin serum concentration versus time curve was best fitted a 2- comparment open model. It is clear that there is no significant differences in the values of distribution rate constant (Ü) and distribution half - life (t{u00BD}Ü) of lincomycin following single oral administration of lincomycin in chickens fed acidifiers containing ration (1ppm) the calculated pharmacokinetic parameters indicated the peak concentration (Cmax) was 5.63 ± 1.42 mg / ml and was achieved at Tmax (0.62 ± 0.23) which is significantly lower (Cmax) and shorter Tmax than chickens fed on free acidifiers

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