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Effect of acidifiers on pharmacokinetic and tissue residues of lincomycin in broiler chickens / Tamer Mohamed Abosreea ; Supervised Aziza Mahrous Mohamed Amer , Salah Eldin Abdelhamid

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Tamer Mohamed Abosreea , 2014Description: 97 P. ; 25cmOther title:
  • تأث{u٠٦أأ}ر المحمضات على حرك{u٠٦أأ}ة و متبق{u٠٦أأ}ات الأنسجة لل{u٠٦أأ}نكوم{u٠٦أأ}س{u٠٦أأ}ن فى بدارى الدجاج [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology Summary: Pharmacokinetics of lincomycin was studied following single i.v and oral administrations (20 mg / kg b.wt) in both control and gallimix (as acidifier) in medicated broiler chickens. Lincomycin serum concentration was determined by microbiological assay method. Following i.v. injection in group fed free acidifiers and acidifiers containing ration, lincomycin serum concentration versus time curve was best fitted a 2- comparment open model. It is clear that there is no significant differences in the values of distribution rate constant (Ü) and distribution half - life (t{u00BD}Ü) of lincomycin following single oral administration of lincomycin in chickens fed acidifiers containing ration (1ppm) the calculated pharmacokinetic parameters indicated the peak concentration (Cmax) was 5.63 ± 1.42 mg / ml and was achieved at Tmax (0.62 ± 0.23) which is significantly lower (Cmax) and shorter Tmax than chickens fed on free acidifiers
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.15.M.Sc.2014.Ta.E (Browse shelf(Opens below)) Not for loan 01010110064078000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.10.15.M.Sc.2014.Ta.E (Browse shelf(Opens below)) 64078.CD Not for loan 01020110064078000

Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology

Pharmacokinetics of lincomycin was studied following single i.v and oral administrations (20 mg / kg b.wt) in both control and gallimix (as acidifier) in medicated broiler chickens. Lincomycin serum concentration was determined by microbiological assay method. Following i.v. injection in group fed free acidifiers and acidifiers containing ration, lincomycin serum concentration versus time curve was best fitted a 2- comparment open model. It is clear that there is no significant differences in the values of distribution rate constant (Ü) and distribution half - life (t{u00BD}Ü) of lincomycin following single oral administration of lincomycin in chickens fed acidifiers containing ration (1ppm) the calculated pharmacokinetic parameters indicated the peak concentration (Cmax) was 5.63 ± 1.42 mg / ml and was achieved at Tmax (0.62 ± 0.23) which is significantly lower (Cmax) and shorter Tmax than chickens fed on free acidifiers

Issued also as CD

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