Diagnosis of bladder cancer using nanotechnology / Ahmed Ibrahim Abdelfattah Nossier ; Supervised Mohamed Ahmed Hamdy , Manal Fouad Ismail , Sanaa Eissa Mohamed

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Ahmed Ibrahim Abdelfattah Nossier

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TextLanguage: English Publication details: Cairo : Ahmed Ibrahim Abdelfattah Nossier , 2014Description: 229 P. : charts , facsimiles ; 25cmOther title:

تشخيص سرطان المثانة باستخدام تكنولوجيا النانو [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry Summary: Hyaluronidase (HAase) was reported as a urinary marker of bladder cancer. In this study, a simple colorimetric gold nanoparticle (AuNP) assay was developed for rapid and sensitive detection of urinary HAase activity. Charge interaction between polyanionic hyaluronic acid (HA) and cationic AuNPs stabilized with cetyl trimethyl ammonium bromide (CTAB) led to formation of gold aggregates and a red to blue color shift. HAase digests HA into small fragments preventing the aggregation of cationic AuNPs. The nonspecific aggregation of AuNPs in urine samples was overcome by pre-treatment of samples with the polycationic chitosan that was able to agglomerate all negatively charged interfering moieties before performing the assay

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.08.01.Ph.D.2014.Ah.D (Browse shelf(Opens below))		Not for loan	01010110064084000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.08.01.Ph.D.2014.Ah.D (Browse shelf(Opens below))	64084.CD	Not for loan	01020110064084000

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Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry

Hyaluronidase (HAase) was reported as a urinary marker of bladder cancer. In this study, a simple colorimetric gold nanoparticle (AuNP) assay was developed for rapid and sensitive detection of urinary HAase activity. Charge interaction between polyanionic hyaluronic acid (HA) and cationic AuNPs stabilized with cetyl trimethyl ammonium bromide (CTAB) led to formation of gold aggregates and a red to blue color shift. HAase digests HA into small fragments preventing the aggregation of cationic AuNPs. The nonspecific aggregation of AuNPs in urine samples was overcome by pre-treatment of samples with the polycationic chitosan that was able to agglomerate all negatively charged interfering moieties before performing the assay

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