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Detection of hepatitis C virus (HCV) in Saliva with different viral loads in serum of hepatitis C patients / Rania "Ahmed Talaat" Abdelzaher Mohamed ; Supervised Elsayed Tarek Abdelsalam , Maha Mohammed Gaafar

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rania Ahmed Talaat Abdelzaher Mohamed , 2012Description: 114 P. : charts ; 25cmOther title:
  • الكشف عن فيروس ج فى لعاب مرشى فيروس ج ذوى المستويات المختلفة من الاصابة الفيروسية فى الدم [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Botany - Microbiology Summary: Hepatitis C virus is the most common cause of liver disease today. Although is believed to primarily transmitted through blood to blood contact, there are indications that other means help in hepatitis C transmission. In nearly half of the cases hepatitis C, the infected individuals cannot identify the source of their infection while it is believed that most cases are due to risk factors involving contaminated blood so it is interested to those concerned with the number one cause of liver disease is possibility of transmitting of Hepatitis C Virus (HCV) via saliva. In this study HCV-RNA in saliva from plasma HCVRNA positive patients was tested by conventional PCR. HCV-RNA was detected in 32out of 49 saliva specimens (65.3%). No correlation was found between the presences of HCV in saliva and age, gender, and transaminase values. A statically significant relation between plasma HCV-RNA viral load and saliva HCV-RNA detection was observed (p=0.034). In conclusion: Although our study supports the concept of shedding of the virus in saliva of HCV patients, more investigations on the biological factors possibly involved in mucosal transmission of HCV are recommended for definitive conclusion
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.05.M.Sc.2012.Ra.D (Browse shelf(Opens below)) Not for loan 01010110064017000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.05.M.Sc.2012.Ra.D (Browse shelf(Opens below)) 64017.CD Not for loan 01020110064017000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Botany - Microbiology

Hepatitis C virus is the most common cause of liver disease today. Although is believed to primarily transmitted through blood to blood contact, there are indications that other means help in hepatitis C transmission. In nearly half of the cases hepatitis C, the infected individuals cannot identify the source of their infection while it is believed that most cases are due to risk factors involving contaminated blood so it is interested to those concerned with the number one cause of liver disease is possibility of transmitting of Hepatitis C Virus (HCV) via saliva. In this study HCV-RNA in saliva from plasma HCVRNA positive patients was tested by conventional PCR. HCV-RNA was detected in 32out of 49 saliva specimens (65.3%). No correlation was found between the presences of HCV in saliva and age, gender, and transaminase values. A statically significant relation between plasma HCV-RNA viral load and saliva HCV-RNA detection was observed (p=0.034). In conclusion: Although our study supports the concept of shedding of the virus in saliva of HCV patients, more investigations on the biological factors possibly involved in mucosal transmission of HCV are recommended for definitive conclusion

Issued also as CD

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