Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry

The aim of the work is to examine the validity of leptin and nitric oxide as biochemical markers for the activity and severity of bronchial asthma in adults. Eighty subjects were participated in the study, their age ranged between 28-52 years, and having normal weight with BMI{u2264}24.9 Kg/m2. They were divided into two groups: Group (A): Included twenty healthy normal subjects (9 males and 11 females), and Group (B): Consisted of sixty asthmatic patients (26 males and 34 females), they were divided according to their degree of asthma severity into three subgroups: Group (B-1): Included twenty controlled asthmatic patients, Group (B-2): Included twenty partially controlled asthmatic patients, and Group (B-3): Consisted of twenty uncontrolled asthmatic patients. The results showed that serum levels of leptin and nitric oxide were significantly higher in the asthmatic patients than in the normal subjects. Furthermore, uncontrolled asthmatic patients had significantly higher levels than that for the partially controlled and the controlled asthmatic patients. Also partially controlled asthmatic patients had significantly higher levels as compared to controlled ones; it was found that there were statistical significant sex difference in serum leptin levels among asthmatic patients and control subjects

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