Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anesthesia

Objectives: Our aim is to compare between the effects of intraoperative intravenous N-acetylsysteine infusion to intravenous prostaglandin E1 infusion for prevention of renal injury in patients undergoing abdominal aortic surgery with infrarenal aortic cross clamping. Patients & Methods: After approval of our Departmental Ethics and Research Committee, written informed consents were obtained from patients. Thirty patients were enrolled in the controlled randomized study. There were 26 male and 4 female patients with a mean age of 52.056 ±9.40 years scheduled for abdominal aortic surgery with infrarenal aortic cross-clamping with normal preoperative serum creatinine level (<1.5 mg/dl). ), patients were randomly assigned into three equal groupseach containing 10 patients as follows: Control group in which patients were received saline infusion at a rate of 2 ml/Kg/h after skin incision till 30 min after aortic de-clamping, NAC group in which patients were received N-acetylcysteine(FLUIMUCIL® 5g/25ml,Zambon)after skin incision at a dose of 150mg/kg infused in 20 min, followedby an infusion of 20 mg/kg/h till 30 min after aortic de-clamping, and PGE1 group in which patients were received PGE1 (PROSTIN*VR, 0.5mg/mL, Pfizer) after skin incision at a dose of 20 ng/Kg/min till 30 min after aortic de-clamping

Issued also as CD