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Alteration of B and T cell markers in chronic granulomatous disease (CGD) patients / Diana Nagy Garas Masoud ; Supervised Reem Jan Farid , Engy Mohamed Fekry , Aisha Mahmoud Khairy Elmarsfy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Diana Nagy Garas Masoud , 2014Description: 138 Leaves : charts ; 25cmOther title:
  • فى الداء الحبيبى المزمنT و Bالتغير فى أنواع و طبيعة و مستوى نضوج الخلايا المناعية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Clinical and Chemical Pathology Summary: Primary immunodeficiency disorder (PID) refers to a heterogeneous group of disorders characterized by poor or absent function in one or more components of the immune system.Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder caused by inherited defects in the NADPH oxidase complex.CD27 is considered an immunophenotypic marker identifying peripheral blood memory B cells.In humans, differentially spliced isoforms of the leukocyte common Ag (CD45) have been used to discriminate populations that were thought to represent naive and memory cells. CD45RA is expressed on naïve T cells, as well as the effector cells in both CD4 and CD8. After antigen experience, central and effector memory T cells gain expression of CD45RO and lose expression of CD45RA. Aim of work The aim of the study was to identify the alteration in peripheral blood B and T cell compartments in patients with CGD (to detect CD45RO versus CD45RA &to identify alteration in CD27 in CGD patients)
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Di.A (Browse shelf(Opens below)) Not for loan 01010110064060000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Di.A (Browse shelf(Opens below)) 64060.CD Not for loan 01020110064060000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Clinical and Chemical Pathology

Primary immunodeficiency disorder (PID) refers to a heterogeneous group of disorders characterized by poor or absent function in one or more components of the immune system.Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder caused by inherited defects in the NADPH oxidase complex.CD27 is considered an immunophenotypic marker identifying peripheral blood memory B cells.In humans, differentially spliced isoforms of the leukocyte common Ag (CD45) have been used to discriminate populations that were thought to represent naive and memory cells. CD45RA is expressed on naïve T cells, as well as the effector cells in both CD4 and CD8. After antigen experience, central and effector memory T cells gain expression of CD45RO and lose expression of CD45RA. Aim of work The aim of the study was to identify the alteration in peripheral blood B and T cell compartments in patients with CGD (to detect CD45RO versus CD45RA &to identify alteration in CD27 in CGD patients)

Issued also as CD

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