Enhancement of neural stem cells after induction of depression in male albino rats / Alshaymaaa Gamal Aboulkhair , Supervised Zeinab Mohamed Kamel Ismail , Mohammed Diaa Eldin Mohamed , Mary Attia Morcos

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Alshaymaaa Gamal Aboulkhair

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TextLanguage: English Publication details: Cairo : Alshaymaaa Gamal Aboulkhair , 2014Description: 237 P. : charts , facsimiles ; 25cmOther title:

حث الخلايا الجذعية العصبية بعد اصابة ذكور الفئران البيضاء بالإكتئاب [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology Summary: Background and Objectives: Depression is one of the most prevalent psychiatric disorders. Endogenous neural stem cells (NSCs) could replace damaged Hippocampal neurons in depression. This work was planned to evaluate Rhodiola rosea (Rr) extract and Acetyl-L-Carnitine (ALC) possible role in stimulation of NSCs proliferation and in depression improvement. Methods and Results: Forty adult male albino rats were divided into four groups; control, untreated depressed model, Rr model and ALC model. After depression induction by chronic mild stress, rats received Rr extract 1.5g/kg/day or ALC 100mg/kg/day for three weeks. The sucrose preference test (SP) was done before, after depression induction and 3 weeks after supplementation of drugs. The brain was removed and processed for H&E, Toluidine blue and immunohistochemical staining for caspase 3, glial fibrillary acid protein and proliferating cell nuclear antigen +ve cells. Sucrose preference improved in Rr and ALC group. The undamaged neurons were increased while dark neurons were decreased in both groups. Caspase 3 +ve cells were not detected in Rr group and decreased in ALC group. GFAP +ve cells were increased in both groups. PCNA +ve cells were detected only in Rr group

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.16.Ph.D.2014.Al.E (Browse shelf(Opens below))		Not for loan		01010110064063000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.11.16.Ph.D.2014.Al.E (Browse shelf(Opens below))	64063.CD	Not for loan		01020110064063000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Histology

Background and Objectives: Depression is one of the most prevalent psychiatric disorders. Endogenous neural stem cells (NSCs) could replace damaged Hippocampal neurons in depression. This work was planned to evaluate Rhodiola rosea (Rr) extract and Acetyl-L-Carnitine (ALC) possible role in stimulation of NSCs proliferation and in depression improvement. Methods and Results: Forty adult male albino rats were divided into four groups; control, untreated depressed model, Rr model and ALC model. After depression induction by chronic mild stress, rats received Rr extract 1.5g/kg/day or ALC 100mg/kg/day for three weeks. The sucrose preference test (SP) was done before, after depression induction and 3 weeks after supplementation of drugs. The brain was removed and processed for H&E, Toluidine blue and immunohistochemical staining for caspase 3, glial fibrillary acid protein and proliferating cell nuclear antigen +ve cells. Sucrose preference improved in Rr and ALC group. The undamaged neurons were increased while dark neurons were decreased in both groups. Caspase 3 +ve cells were not detected in Rr group and decreased in ALC group. GFAP +ve cells were increased in both groups. PCNA +ve cells were detected only in Rr group

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