header
Image from OpenLibrary

The impact of p-53 pathway genes polymorphism on the clinical outcome in adult patients with acute myeloid leukemia / Mostafa Magdy Mohamed Saber ; Supervised Thorya Abdelhamid , Gamal Ebid , Mosaad Elgammal

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mostafa Magdy Mohamed Saber , 2014Description: 147 Leaves : charts ; 30cmOther title:
  • تأثير التغيرات الشكلية للمسار الجينى لمثبت الأورام ب53 على النتائج الاكلينيكية لمرضى اللوكيميا الميلوديه الحادة للبالغين [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology Medical Summary: Introduction: Acute myeloid leukemia (AML) is a highly heterogeneous disease, with biologically and prognostically different subtypes. Many cytogenetic studies have been implicated to clinical outcome in AML. p53 gene pathway has been proved in many cancers to have an impact on survival. Aim of work: To study the impact of p53, p21 and mdm2 gene polymorphism on clinical outcome in adults with AML treated at National Cancer Institute -Cairo University. Methods: All patients presented to Medical Oncology department-NCI from April 2010 till November 2011. Clinical data and bone marrow samples were obtained. Molecular genetic analysis involving P53, MDM2 and P21 single nucleotide gene polymorphism will be done using PCR-RFLP coupled analysis. Clinical follow up was done for a period of 1 year (0.5 - 12 months)
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.04.M.Sc.2014.Mo.I (Browse shelf(Opens below)) Not for loan 01010110064221000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.04.M.Sc.2014.Mo.I (Browse shelf(Opens below)) 64221.CD Not for loan 01020110064221000

Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology Medical

Introduction: Acute myeloid leukemia (AML) is a highly heterogeneous disease, with biologically and prognostically different subtypes. Many cytogenetic studies have been implicated to clinical outcome in AML. p53 gene pathway has been proved in many cancers to have an impact on survival. Aim of work: To study the impact of p53, p21 and mdm2 gene polymorphism on clinical outcome in adults with AML treated at National Cancer Institute -Cairo University. Methods: All patients presented to Medical Oncology department-NCI from April 2010 till November 2011. Clinical data and bone marrow samples were obtained. Molecular genetic analysis involving P53, MDM2 and P21 single nucleotide gene polymorphism will be done using PCR-RFLP coupled analysis. Clinical follow up was done for a period of 1 year (0.5 - 12 months)

Issued also as CD

There are no comments on this title.

to post a comment.