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Mesenchymal stromal cell expression of indoleamine 2,3 dioxygenase and regulatory T cells in acute myeloid leukemia / Lamyaa Hany Abdellatif ; Supervised Iman Maher Mansour , Rania Ahmed Zayed , Fadwa Saeid Abdelazim

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Lamyaa Hany Abdellatif , 2014Description: 136 P. : charts ; 25cmOther title:
  • دراسة تعبير ال{u٠٦ئ٣}:{u٠٦ئ٢} اندولامين دى اكسيجيناز فى الخلايا المتوسطية و علاقته بالخلايا التائية التنظيمية فى حالات سرطان الدم الميلودى [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: The microenvironment of acute myelogenous leukemia (AML) is suppressive for immune effector cells. Regulatory T cells (Tregs) have been recognized as a contributor factor and may be recruited and exploited by leukemic cells to evade immunesurveillance. The mesenchymal stromal cells (MSCs), the second largest population of long lived stem / progenitor cells in the bone marrow play an important role in immunomodulation of the microenvironment as they can promote differentiation of CD4 + CD25 + regulatory T - cell subsets via the indoleamine 2,3- dioxygenase (IDO) pathway. The aim of the present work was to evaluate the expression of indoleamine dioxygenase in bone marrow derived MSCs and to study its correlation to percent of regulatory T cells
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.La.M (Browse shelf(Opens below)) Not for loan 01010110064339000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.La.M (Browse shelf(Opens below)) 64339.CD Not for loan 01020110064339000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

The microenvironment of acute myelogenous leukemia (AML) is suppressive for immune effector cells. Regulatory T cells (Tregs) have been recognized as a contributor factor and may be recruited and exploited by leukemic cells to evade immunesurveillance. The mesenchymal stromal cells (MSCs), the second largest population of long lived stem / progenitor cells in the bone marrow play an important role in immunomodulation of the microenvironment as they can promote differentiation of CD4 + CD25 + regulatory T - cell subsets via the indoleamine 2,3- dioxygenase (IDO) pathway. The aim of the present work was to evaluate the expression of indoleamine dioxygenase in bone marrow derived MSCs and to study its correlation to percent of regulatory T cells

Issued also as CD

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