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Urinary transforming growth factor beta-1 as a marker of renal dysfunction in sickle cell disease / Nesma Ahmed Fouad Mubarak ; Supervised Ahmed Maher Kaddah , Emad Emil Ghobrial , Hanan Abdelaziz

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Nesma Ahmed Fouad Mubarak , 2014Description: 182 P. : charts , facsimiles ; 25cmOther title:
  • دور عامل النمو المتحول بيتا - واحد في البول كعلامة علي اختلال وظائف الكلى فى المرضى المصابين بأنيميا الخلايا المنجلية [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Sickle cell disease (SCD) is a genetic disorder that results in deformity of red blood cells. Renal dysfunction affects 5- 18% of patients with sickle cell disease (SCD). To date, only few studies have described urinary levels of transforming growth factor Ý- 1 (TGF- Ý1), which is a marker of fibrosis, as a biomarker in identifying patients at risk of developing renal disease in SCD. We hypothesized that SCD subjects will have increased urinary excretion of TGF- Ý1 compared with healthy controls. We examined 40 SCD subjects: 21 of them were sickle cell anemia, 16 were sickle thalassemia and 3 were sickle trait, 38 out of the 40 patients (95%) were on hydroxyurea (HU) treatment. We compared them to 20 control children with matched age and sex. The study was held in the time period between May / 2013 and December / 2013
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2014.Ne.U (Browse shelf(Opens below)) Not for loan 01010110064384000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.M.Sc.2014.Ne.U (Browse shelf(Opens below)) 64384.CD Not for loan 01020110064384000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Sickle cell disease (SCD) is a genetic disorder that results in deformity of red blood cells. Renal dysfunction affects 5- 18% of patients with sickle cell disease (SCD). To date, only few studies have described urinary levels of transforming growth factor Ý- 1 (TGF- Ý1), which is a marker of fibrosis, as a biomarker in identifying patients at risk of developing renal disease in SCD. We hypothesized that SCD subjects will have increased urinary excretion of TGF- Ý1 compared with healthy controls. We examined 40 SCD subjects: 21 of them were sickle cell anemia, 16 were sickle thalassemia and 3 were sickle trait, 38 out of the 40 patients (95%) were on hydroxyurea (HU) treatment. We compared them to 20 control children with matched age and sex. The study was held in the time period between May / 2013 and December / 2013

Issued also as CD

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