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YKL - 40 expression and its polymorphism in human breast carcinoma : A potential biomarker / Reham Fares Mohammed Elrouby ; Supervised Olfat Gamil Shaker , Amal Rashad Elshehaby , Amr Aly Zahra

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Reham Fares Mohammed Elrouby , 2014Description: 118 P. : charts , facsimiles ; 25cmOther title:
  • و تعدده الجينى فى أورام الثدى كدلالة كيميائية محتملة YKL- 40 التعبيرالجينى لل [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry Summary: YKL - 40 is an extracelluar matrix glycoprotein with sequence homology to the proteins of the chitinase like family, but has no chitinase activity. It is highly expressed in several types of cancer, including breast cancer. In this study we aim to detect YKL - 40 expression and its polymorphism in metastatic and non - metastatic breast cancer patients and comparing the results with fibroadenoma patients and normal females. The study included 113 female patients, divided into 20 patients with fibroadenoma, 73 non-metastatic and 20 metastatic breast cancer patients. Twenty healthy females were also included and served as control. YKL - 40 level was detected in serum of studied groups using ELISA kit, also DNA extraction was done followed by real time PCR to detect the chitinase 3- like I (rs4950928) polymorphism
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.03.Ph.D.2014.Re.Y (Browse shelf(Opens below)) Not for loan 01010110064389000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.03.Ph.D.2014.Re.Y (Browse shelf(Opens below)) 64389.CD Not for loan 01020110064389000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry

YKL - 40 is an extracelluar matrix glycoprotein with sequence homology to the proteins of the chitinase like family, but has no chitinase activity. It is highly expressed in several types of cancer, including breast cancer. In this study we aim to detect YKL - 40 expression and its polymorphism in metastatic and non - metastatic breast cancer patients and comparing the results with fibroadenoma patients and normal females. The study included 113 female patients, divided into 20 patients with fibroadenoma, 73 non-metastatic and 20 metastatic breast cancer patients. Twenty healthy females were also included and served as control. YKL - 40 level was detected in serum of studied groups using ELISA kit, also DNA extraction was done followed by real time PCR to detect the chitinase 3- like I (rs4950928) polymorphism

Issued also as CD

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