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Study of glutathione S- transferase gene polymorphisms in sickle cell anemia patients / Rasha Abdalghani Ali Abdalrahman ; Supervised Hala Fathy Shiba , Somaia Abdalrahman Mousa , Mona Kamal Elghamrawy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rasha Abdalghani Ali Abdalrahman , 2014Description: 127 P. : charts , facsimiles ; 25cmOther title:
  • دراسة الأشكال المتعددة لجين الجلوتاثيون إس {u٢٠١٣} ترانسفيراز فى مرضى أنيميا الخلايا المنجلية [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Sickle cell disease (SCD) complications like vaco - occlusion and ischemia reperfusion injury are associated with generation of reactive oxygen species with subsequent oxidative stress. Glutathione S- Transferases (GSTs) are a group of enzymes that protect against oxidative stress. The aim of this study is to evaluate the prevalence of GSTM1, GSTT1 and GSTP1 gene polymorphisms among homozygous sickle cell anemia (HbSS) patients and to investigate the possible association between the presence of those polymorphisms and SCD severity and complications. Fifty pediatric patients with SCD and 50 controls were studied. Genotyping the polymorphisms in the GSTT1 and GSTM1 genes was performed using multiplex PCR method. The GSTP1 ILe105Val polymorphism was determined using PCR - RFLP
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2014.Ra.S (Browse shelf(Opens below)) Not for loan 01010110064420000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.Ph.D.2014.Ra.S (Browse shelf(Opens below)) 64420.CD Not for loan 01020110064420000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Sickle cell disease (SCD) complications like vaco - occlusion and ischemia reperfusion injury are associated with generation of reactive oxygen species with subsequent oxidative stress. Glutathione S- Transferases (GSTs) are a group of enzymes that protect against oxidative stress. The aim of this study is to evaluate the prevalence of GSTM1, GSTT1 and GSTP1 gene polymorphisms among homozygous sickle cell anemia (HbSS) patients and to investigate the possible association between the presence of those polymorphisms and SCD severity and complications. Fifty pediatric patients with SCD and 50 controls were studied. Genotyping the polymorphisms in the GSTT1 and GSTM1 genes was performed using multiplex PCR method. The GSTP1 ILe105Val polymorphism was determined using PCR - RFLP

Issued also as CD

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