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Synthesis and biological evaluation of some novel phthalimide derivatives incorporated into other heterocycles as anticancer and antimicrobial agents / Basma Serag Eldin Alsayed Habib ; Supervised Kamelia Mahmoud Amin , Afaf Hussein Elmasry

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Basma Serag Eldin Alsayed Habib , 2014Description: 186 P. : photographs ; 25cmOther title:
  • التشييد و التقييم البيولوجى لبعض مشتقات الفثاليميدات المرتبطة مع حلقات غير متجانسة كمضادات للسرطانات و الميكروبات [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: The phthalimide moiety has been utilized extensively in medicinal chemistry and is considered to be a privileged structure that shows various pharmacological activities including anti inflammatory, hypoglycemic, hypolipidemic, anticonvulsant, anxiolytic, antiviral, antitumor and antimicrobial activity. Therefore, we are considered with the synthesis of novel series of substituted (4- substituted phenylamino) methyl phthalimides with the objective of discovering novel antitumor antimicrobial agents. Moreover docking of the some biologically tested compounds into the active site of GyrB enzyme was performed to correlate the docking results with the biological results
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2014.Ba.S (Browse shelf(Opens below)) Not for loan 01010110064580000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2014.Ba.S (Browse shelf(Opens below)) 64580.CD Not for loan 01020110064580000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

The phthalimide moiety has been utilized extensively in medicinal chemistry and is considered to be a privileged structure that shows various pharmacological activities including anti inflammatory, hypoglycemic, hypolipidemic, anticonvulsant, anxiolytic, antiviral, antitumor and antimicrobial activity. Therefore, we are considered with the synthesis of novel series of substituted (4- substituted phenylamino) methyl phthalimides with the objective of discovering novel antitumor antimicrobial agents. Moreover docking of the some biologically tested compounds into the active site of GyrB enzyme was performed to correlate the docking results with the biological results

Issued also as CD

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