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Synthesis and biological evaluation of some pyridopyrimidine derivatives of anticipated antitumor activity / Mohamed Fares Mahmoud Mohamed Metwaly ; Supervised Safinaz Elsayed Abbas , Sahar Mahmoud AbouSeri , Hatem Abdelkader Abdelaziz

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Fares Mahmoud Mohamed Metwaly , 2014Description: 118 P. : photographs ; 25cmOther title:
  • تشييد و تقييم بيولوجى لبعض مشتقات البيريدوبيريميدين المتوقع لها فعالية كمضادات للأورام [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry Summary: This thesis is concerned with synthesis of a new series of 2- (2- arylide nehydrazinyl) pyrido [2, 3- d] pyrimidines Va - e and pyrido[2, 3- d] [1, 2, 4] triazolo[4, 3- a]pyrimidines VI - XII and evaluation for their cytotoxic activity against two cancer cell lines, namely PC - 3 prostate cancer and A- 549 lung cancer. Most of the tested compounds displayed noticeable growth inhibitory activity against PC - 3 cells. In particular, 4- (3- Acetyl - 5- o x o - 6- phenyl - 8- (thiophen- 2- yl) pyrido[2, 3- d][1, 2, 4] triazolo [4, 3- a] pyrimidin - 1(5H)- yl)benzenesulfonamide XIIf exhibited superior antitumor activity against PC - 3 cells at submicromolar level (IC50 = 0.356 æM). The detailed biological aspects of the promising compound XIIf on the PC - 3 cell line were studied. The data indicated that XIIf was able to cause cell cycle arrest and induced cancer cell apoptosis via caspase - 3 dependent pathway
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2014.Mo.S (Browse shelf(Opens below)) Not for loan 01010110064747000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.05.M.Sc.2014.Mo.S (Browse shelf(Opens below)) 64747.CD Not for loan 01020110064747000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry

This thesis is concerned with synthesis of a new series of 2- (2- arylide nehydrazinyl) pyrido [2, 3- d] pyrimidines Va - e and pyrido[2, 3- d] [1, 2, 4] triazolo[4, 3- a]pyrimidines VI - XII and evaluation for their cytotoxic activity against two cancer cell lines, namely PC - 3 prostate cancer and A- 549 lung cancer. Most of the tested compounds displayed noticeable growth inhibitory activity against PC - 3 cells. In particular, 4- (3- Acetyl - 5- o x o - 6- phenyl - 8- (thiophen- 2- yl) pyrido[2, 3- d][1, 2, 4] triazolo [4, 3- a] pyrimidin - 1(5H)- yl)benzenesulfonamide XIIf exhibited superior antitumor activity against PC - 3 cells at submicromolar level (IC50 = 0.356 æM). The detailed biological aspects of the promising compound XIIf on the PC - 3 cell line were studied. The data indicated that XIIf was able to cause cell cycle arrest and induced cancer cell apoptosis via caspase - 3 dependent pathway

Issued also as CD

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