Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Chest Diseases Tuberculosis

Assessing the function of the right side of the heart .along with diagnosing of pulmonary hypertension and studying the hemodynamic abnormalities, thus Studying functional limitations of pulmonary hypertension on COPD patients. Data from 51 COPD male patients between December 2012 and April 2013 was reviewed. PFTs (post bronchodilators FEV1 {u2264} 0.7), echo, BODE index were obtained, RHC was done only for 17 patients after their echo revealed PASP {u2265} 45 mmHg. We found 11 patients (21.5%) had MPAP {u2265} 25 mmHg by RHC (35.27 ± 7.837) and 2 patients (~ 4%) had severe PH (MPAP {u2265}40mmHg).the mean age 62(±9.16) with smoking index 34(± 6.5). 63% of the patients had PASP {u2265} 35 mmHg by echocardiography while 24 patients (47%) ha PASP {u2265}45 mmHg. COPD patients with PH were more hypoxemic(53.73 ± 6.214 vs. 62.51 ± 10.999, p - value0.00013), showed increased BODE index(8.45 ± 1.572 vs. 6.31 ± 2.604, p - value0.0015), showed statistically significant difference in both BRV and LRV (3.725 ± 0.8625 vs. 4.500 ± 0.9849 p - value 0.0304 and 6.067 ± 0.9923 vs. 6.927 ± 0.7888 0.006 respectively), showed significant difference in the measurement of tAPSE (2.055 ± 0.5298, 3.142 ± 0.3437 with p-value < 0.0001) as compared to COPD patients without PH. linear correlation between PaO2 and BODE index with MPAP was noticed

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