Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology

The aim of the present research was to compare the osteoconductivity of both bio - gen and nano bone after implantation in experimental osseous defects in rabbit tibia. Thirty adult male New zealand white rabbits were used in the study. Two holes, 1 cm apart, were created in each tibia reaching the bone marrow. The lower hole of the right tibia was packed with bio - gen material, while the upper hole was left empty to serve as control. In the left tibia nano bone was packed in the lower hole while the upper hole was left empty to serve as control. Histological analysis revealed a more accelerated pattern of bone healing in the graft augmented bone defects as compared to the control defects. Furthermore, the Nano - bone augmented defect showed a more advanced pattern of bone healing than the bio - gen augmented bone defects histomorphometric analysis showed the highest bone area percentage in the nano bone defect, followed by the bio - gen defect and the control defect. Furthermore, the highest bone mineral density was recorded in the nano bone defect followed by the Bio-gen and the control defects

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