Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Endodontics

Objectives: The aim of this in-vivo study was to prepare specified standardized extracts from certain natural plants: (Green tea leaves, Cinnamon bark and Olive leaves) and to compare them with calcium hydroxide intra-canal medicament regarding: The biocompatibility of these drugs and their antimicrobial activity. Materials and methods: In the first part of the study, the selected drugs were air dried, cut into pieces and ground into powder form. The extracts were prepared using different solvents, fractionated using solvents of different polarity .Then, screened against different bacteria and the most potent extracts were chosen for the study. In the second part of the study, the subcutaneous implantation technique was carried out on forty male albino Sprague-Dawley rats. The rats were classified into four groups, ten rats each, according to the tested material and the experimental period: Group I: Green tea extract, cinnamon bark extract and negative control. (14 days observation period), Group II: Olive leaves extract, Meta paste and negative control (14 days observation period), Group III: same as Group I (30 days observation period) and Group IV: same as Group II (30 days observation period). In the third part of the study, thirty two patients free of systemic diseases were selected. All the selected upper anterior teeth were diagnosed as having pulpal necrosis

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