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Fabrication of a bioactive composite scaffold for drug delivery / Hoda Gaafar Hassan Hammad ; Supervised Azza Mohamed Abdelzaher Hashem , Amany Abdelmonem Mostafa , Hassane Oudadesse

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hoda Gaafar Hassan Hammad , 2014Description: 211 Leaves : charts , photographs ; 30cmOther title:
  • تصنيع سقالة كمبوزيت ذات نشاط بيولوچى لإطلاق العقاقير [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Dental Materials Summary: The objective of this study was to fabricate of a bioactive composite scaffold for drug delivery aiming that the innovated tissue engineering scaffold be bifunctional. That innovated biocomposite scaffold should offer both good bioactivity to enhance cell adhesion, differentiation and proliferation as well as antimicrobial activity as a local drug delivery system to prevent bone infections and osteomyelitis at the surgical site of scaffold implantation. The bioactive composite scaffolds was fabricated from the chitosan polymer (which offered a biocompatible and biodegradable polycationic matrix) and the 46S6 bioactive glass (which provided bioactivity, improved the compressive strength and hindered the rapid ex vivo biodegradation of the prepared scaffold in order to enhance bone regeneration in stress bearing areas) and finally the GS drug as local antibiotic (which is prophylactic against the surgery accompanied sepsis
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.09.10.Ph.D.2014.Ho.F (Browse shelf(Opens below)) Not for loan 01010110064937000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.09.10.Ph.D.2014.Ho.F (Browse shelf(Opens below)) 64937.CD Not for loan 01020110064937000

Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Dental Materials

The objective of this study was to fabricate of a bioactive composite scaffold for drug delivery aiming that the innovated tissue engineering scaffold be bifunctional. That innovated biocomposite scaffold should offer both good bioactivity to enhance cell adhesion, differentiation and proliferation as well as antimicrobial activity as a local drug delivery system to prevent bone infections and osteomyelitis at the surgical site of scaffold implantation. The bioactive composite scaffolds was fabricated from the chitosan polymer (which offered a biocompatible and biodegradable polycationic matrix) and the 46S6 bioactive glass (which provided bioactivity, improved the compressive strength and hindered the rapid ex vivo biodegradation of the prepared scaffold in order to enhance bone regeneration in stress bearing areas) and finally the GS drug as local antibiotic (which is prophylactic against the surgery accompanied sepsis

Issued also as CD

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