Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology (Medical

The aim of this retrospective study is to clarify, report and evaluate the results of allogeneic stem cell transplantation compared with intensive chemotherapy as post - remission treatment (consolidation treatment) for young adults (18 - 55 years) with acute myeloid leukemia (AML) in the years between 2007 and 2010, in an attempt to determine the more effective approach in maintaining disease remission in Egyptian adult AML patients, and which modality of treatment has less impact on the patient well-being. That will be shown by comparing patients whom were subjected to allogeneic stem cell transplantation to those treated by consolidation chemotherapy as regard disease free survival and overall survival after a 3 - year period of follow up. AML is a disease affecting myeloid hematopoietic stem cells resulting in defective function of all cell lines. This thesis includes 141 patients (males and females) presenting in NCI and Nasser Institute between 2007 and 2010. The median age for patients received consolidation chemotherapy and patients underwent HSCT was 34.5 and 29.4, respectively. M2 was the most common subtype in both groups. All cases reached CR after induction chemotherapy. All cases with available donor underwent HSCT while those without donor received consolidation chemotherapy. HSCT is a better choice for AML patients with available donor

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