Enhancement of cancer therapy using multifunctional gold nanoparticles formulations / Noha Mohamed Sayed Mohamed ; Supervised Ahmed soltan Monem , Nihal Saad Elbialy

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Noha Mohamed Sayed Mohamed

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TextLanguage: English Publication details: Cairo : Noha Mohamed Sayed Mohamed , 2014Description: 207 P. : charts , facsimiles ; 25cmOther title:

تحسين علاج السرطان باستخدام تحضيرات جزيئات الذهب متعددة الوظائف [Added title page title]

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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics Summary: Current non-targeted chemotherapy and radiotherapy protocols causes marked cytotoxicity to critical organs in human. This thesis advances two multifunctional near infra-red (NIR) absorbing gold nanoparticles to target breast cancer cells in-vitro and Ehrlich carcinoma in-vivo. The two developed formulations, gold nanoshells with mesoporous silica core (PEG-DOX-MPS-GNSs) and gold nanorods coated mesoporous silica (pGNRs@mSiO2-DOX), can both convert near infrared light energy into heat causing thermal damage to cancerous cells. Further, the incorporated mesoporous silica exhibit high drug loading capacity that can specifically deliver the anticancer drug doxorubicin into tumor site and release it in response to the acidic tumor microenvironment

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Item type	Current library	Home library	Call number	Copy number	Status	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.04.Ph.D.2014.No.E (Browse shelf(Opens below))		Not for loan	01010110065067000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.12.04.Ph.D.2014.No.E (Browse shelf(Opens below))	65067.CD	Not for loan	01020110065067000

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Previous	Cai01.12.04.Ph.D.2014.Mo.E Enhancement of the therapeutic efficacy of anticancer drug using magnetic gold nanocarriers /	Cai01.12.04.Ph.D.2014.Mo.E Evaluation of mega voltage dose accompanying different radiotherapy techniques /	Cai01.12.04.Ph.D.2014.Mo.E Evaluation of mega voltage dose accompanying different radiotherapy techniques /	Cai01.12.04.Ph.D.2014.No.E Enhancement of cancer therapy using multifunctional gold nanoparticles formulations /	Cai01.12.04.Ph.D.2014.No.E Enhancement of cancer therapy using multifunctional gold nanoparticles formulations /	Cai01.12.04.Ph.D.2015.Ba.F Force field development for biological molecules /	Cai01.12.04.Ph.D.2015.Ba.F Force field development for biological molecules /	Next

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics

Current non-targeted chemotherapy and radiotherapy protocols causes marked cytotoxicity to critical organs in human. This thesis advances two multifunctional near infra-red (NIR) absorbing gold nanoparticles to target breast cancer cells in-vitro and Ehrlich carcinoma in-vivo. The two developed formulations, gold nanoshells with mesoporous silica core (PEG-DOX-MPS-GNSs) and gold nanorods coated mesoporous silica (pGNRs@mSiO2-DOX), can both convert near infrared light energy into heat causing thermal damage to cancerous cells. Further, the incorporated mesoporous silica exhibit high drug loading capacity that can specifically deliver the anticancer drug doxorubicin into tumor site and release it in response to the acidic tumor microenvironment

Issued also as CD

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