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The role of angiotensin converting enzyme gene polymorphism as a risk factor for type ii diabetes mellitus / Raghda Atef Mohamed Kamel ; Supervised Lamiaa Ali Mansour , Dalia Ahmed Hamed Ali , Ola Moebed Elgarhy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Raghda Atef Mohamed Kamel , 2014Description: 109 P. : charts , facsimiles ; 25cmOther title:
  • التوزيع الوراثى للتحور الجينى للإنزيم المحول للأنجيوتنسين فى مرضى السكر من النوع الثانى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: Angiotensin converting enzyme is identified as the key component of the renin-angiotensin system whose main function was to process angiotensin I to angiotensin II and degrades bradykinin. Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. To explore the role of ACE gene polymorphism as a risk factor for type II DM. ACE gene polymorphism was estimated on 40 type II diabetic patients and 20 healthy control subjects, using real time PCR syber green technique. The frequencies of the ACE genotypes II, DD, ID, I allele and D allele did not differ significantly between cases and controls. Albumin/Creatinine ratio showed a statistically significant difference between cases and controls with p < 0.001. Our results revealed that Angiotensin converting enzyme gene polymorphism is not associated with increased risk neither for type II diabetes mellitus nor for diabetic nephropathy in both genotypes and alleles
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Ra.R (Browse shelf(Opens below)) Not for loan 01010110065164000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Ra.R (Browse shelf(Opens below)) 65164.CD Not for loan 01020110065164000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

Angiotensin converting enzyme is identified as the key component of the renin-angiotensin system whose main function was to process angiotensin I to angiotensin II and degrades bradykinin. Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. To explore the role of ACE gene polymorphism as a risk factor for type II DM. ACE gene polymorphism was estimated on 40 type II diabetic patients and 20 healthy control subjects, using real time PCR syber green technique. The frequencies of the ACE genotypes II, DD, ID, I allele and D allele did not differ significantly between cases and controls. Albumin/Creatinine ratio showed a statistically significant difference between cases and controls with p < 0.001. Our results revealed that Angiotensin converting enzyme gene polymorphism is not associated with increased risk neither for type II diabetes mellitus nor for diabetic nephropathy in both genotypes and alleles

Issued also as CD

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