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Preparation and characterization of different pharmaceutical formulations of baclofen via skin route Thesis / Samar Mohamed Nasrallah Abdelrhaman ; Supervised Mohamed Ahmed Elnabrawi , Mohamed Shafik Elraidy , Ehab Rasmy Bendas

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Samar Mohamed Nasrallah Abdelrhaman , 2014Description: 274 P. : charts , facsimiles ; 26cmOther title:
  • تحضير وتوصيف صياغات صيدلانية مختلفة من عقار الباكلوفين لاستخدامها عن طريق الجلد [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: The aim of the present study was to formulate topical gel containing baclofen niosomes. Baclofen is a direct agonist at GAPAB receptors with an anti-inflammatory effect. Baclofen has narrow therapeutic index and many gastrointestinal side effects. The current market products of baclofen are intrathecal injection and oral tablets which cause many problems after their administration. Thus, niosomal formulation as carriers for the topical delivery of baclofen will improve its efficacy, as anti-inflammatory. This was achieved through the encapsulation of baclofen in niosomes aiming at prolonging its action and avoiding most of its side effects. The baclofen niosomes were prepared by altering the ratios between various non-ionic surfactants (Span 60, 40), cholesterol and charge inducing agents using thin film hydration method, the prepared niosomal formulations were evaluated for their encapsulation efficiency and high drug EE% were found, and characterized by transmission electron microscopy, differential scanning calorimetry, particle size analysis, zeta potential analysis and in vitro release performance
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2014.Sa.P (Browse shelf(Opens below)) Not for loan 01010110065130000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2014.Sa.P (Browse shelf(Opens below)) 65130.CD Not for loan 01020110065130000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

The aim of the present study was to formulate topical gel containing baclofen niosomes. Baclofen is a direct agonist at GAPAB receptors with an anti-inflammatory effect. Baclofen has narrow therapeutic index and many gastrointestinal side effects. The current market products of baclofen are intrathecal injection and oral tablets which cause many problems after their administration. Thus, niosomal formulation as carriers for the topical delivery of baclofen will improve its efficacy, as anti-inflammatory. This was achieved through the encapsulation of baclofen in niosomes aiming at prolonging its action and avoiding most of its side effects. The baclofen niosomes were prepared by altering the ratios between various non-ionic surfactants (Span 60, 40), cholesterol and charge inducing agents using thin film hydration method, the prepared niosomal formulations were evaluated for their encapsulation efficiency and high drug EE% were found, and characterized by transmission electron microscopy, differential scanning calorimetry, particle size analysis, zeta potential analysis and in vitro release performance

Issued also as CD

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