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Study of polymorphic transcripts of spermatogenesis related genes in Egyptian males / Mohamed Kamal Hussein ; Supervised Aliaa Mahmoud Issa , Kamal Zaki Mahmoud Shaeer , Manal Osama El Hamshary

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mohamed Kamal Hussein , 2014Description: 160 P. : charts , facsimiles ; 25cmOther title:
  • دراسة تباين النسخ فى الجينات ذات الصلة بالتكوينات المئوية فى الذكور المصريين [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology Summary: cAMP Responsive element modulator (CREM) is one of the most important transcription factors expressed in male testes, CREM expression switches from a repressor to an activator in testes during spermatogenesis. Eighty eight testicular biopsies were histologically evaluated. Total RNA was extracted and profiled for the presence of CREM activators and/or repressors. Normal spermatogenesis group, representing 20%, of the total studied samples showed expression of normal CREM{uF074}2{uF020}activator with intact transactivating domain and gamma repressor, the same finding with another alpha repressor was detected in Hypospermatogenesis group which was representing 22%, of the total studied samples. Approximately 90% of the Round spermatid maturation arrest group, representing 23% from the total samples, showed only two CREM repressors, the other 10% showed altered CREM{uF074}2 transcripts and one repressor
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2014.Mo.S (Browse shelf(Opens below)) Not for loan 01010110065317000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.21.M.Sc.2014.Mo.S (Browse shelf(Opens below)) 65317.CD Not for loan 01020110065317000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology

cAMP Responsive element modulator (CREM) is one of the most important transcription factors expressed in male testes, CREM expression switches from a repressor to an activator in testes during spermatogenesis. Eighty eight testicular biopsies were histologically evaluated. Total RNA was extracted and profiled for the presence of CREM activators and/or repressors. Normal spermatogenesis group, representing 20%, of the total studied samples showed expression of normal CREM{uF074}2{uF020}activator with intact transactivating domain and gamma repressor, the same finding with another alpha repressor was detected in Hypospermatogenesis group which was representing 22%, of the total studied samples. Approximately 90% of the Round spermatid maturation arrest group, representing 23% from the total samples, showed only two CREM repressors, the other 10% showed altered CREM{uF074}2 transcripts and one repressor

Issued also as CD

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