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Pharmacological interaction between some antidiabetic drugs and some fluoroquinolone antibiotics in diabetic experimental animals / Rasha Rabie Mahmoud Elbetawy ; Supervised Hekma Abd Eltawab , Gamal Abdelhakim , Hala Fahmy Zaki

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Rasha Rabie Mahmoud Elbetawy , 2014Description: 188 P. : charts ; 25cmOther title:
  • التفاعل الدوائى بين بعض العقاقير المضادة لمرض السكرى و بعض المضادات الحيوية الفلوروكينولون فى الحيوانات المصابه تجريبيا بمرض السكرى [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Disturbance in glucose homeostasis is one of the serious outcomes of using fluoroquinolones in diabetes. The study aimed to assess the risk of severe hypoglycemia and oxidative stress among diabetic rats receiving ciprofloxacin or levofloxacin with glimepiride and / or rosiglitazone and to determine the involvement of calcium channels in their actions. Male wistar rats were classified into 13 groups. The 1st group served as control animals; the remaining rats were rendered diabetic by streptozotocin (50 mg / kg; i.p.). Group II received saline (diabetic control), groups III - XIII received glimepiride (0.5 mg/ kg; p.o.), rosiglitazone (4 mg / kg; i.p.), ciprofloxacin (40 mg / kg; i.p.) or levofloxacin (50 mg / kg; i.p.) alone or in combinations, daily for two weeks. Blood and liver samples were collected for estimation of blood lactate dehydrogenase and superoxide dismutase activities and levels of glucose, insulin, lipid peroxides and reduced glutathione, as well as liver glycogen content. In another experiment, samples of pancreas islets were incubated with 100æM of ciprofloxacin or levofloxacin, with or without 50 mM verapamil, at 3mM or 16.7m M glucose for 1 h to assess their effects on insulin release
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2014.Ra.P (Browse shelf(Opens below)) Not for loan 01010110065243000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2014.Ra.P (Browse shelf(Opens below)) 65243.CD Not for loan 01020110065243000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Disturbance in glucose homeostasis is one of the serious outcomes of using fluoroquinolones in diabetes. The study aimed to assess the risk of severe hypoglycemia and oxidative stress among diabetic rats receiving ciprofloxacin or levofloxacin with glimepiride and / or rosiglitazone and to determine the involvement of calcium channels in their actions. Male wistar rats were classified into 13 groups. The 1st group served as control animals; the remaining rats were rendered diabetic by streptozotocin (50 mg / kg; i.p.). Group II received saline (diabetic control), groups III - XIII received glimepiride (0.5 mg/ kg; p.o.), rosiglitazone (4 mg / kg; i.p.), ciprofloxacin (40 mg / kg; i.p.) or levofloxacin (50 mg / kg; i.p.) alone or in combinations, daily for two weeks. Blood and liver samples were collected for estimation of blood lactate dehydrogenase and superoxide dismutase activities and levels of glucose, insulin, lipid peroxides and reduced glutathione, as well as liver glycogen content. In another experiment, samples of pancreas islets were incubated with 100æM of ciprofloxacin or levofloxacin, with or without 50 mM verapamil, at 3mM or 16.7m M glucose for 1 h to assess their effects on insulin release

Issued also as CD

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