Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Periodontology

Atherogenesis represents the main driver for CVDs and may be manifested with acute clinical events as acute coronary syndromes (ACS) and stroke. There is increasing evidence that inflammation plays a key role in the development of atherosclerotic vascular disease from atheroma formation to its rupture and development of clinical events. The aim of this study is to detect the possible association between periodontal disease and ACS in a sample of Egyptian population attending the ICU in the national heart institute - Giza, Egypt and if serum levels of HS - CRP biomarker can participate in possible association between periodontal diseases and ACS. One hundred and twenty seven patients (n =127) participated in this study and were divided into three groups. The ACS group consists of 74 patients taken from the ICU of the national heart institute - Giza, Egypt after being diagnosed with acute coronary syndrome. The control group consists of 43 patients taken from the Department of Oral Medicine and Periodontology, Cairo- University perfectly matching the cardiac group in age, sex, and socioeconomic status but were free from any previous history of cardiovascular disease. A complete medical and periodontal assessment were done for both groups as well as serum sample taken for HS - CRP analysis

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