Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Surgery

Sixty one (61) patients who underwent resective surgery with curative intent for primary oral SCC were included in this study. All patients underwent resection of the tumor with a measured 1 cm margin. Specimens were then submitted for processing and reviewing and histopathologic margins were measured. The closest histopathologic margin was compared with the in situ margin (1 cm) to determine percentage discrepancy. The mean discrepancy between the in situ margins and the histopathological margins of all sites were 66.7% for buccal mucosa with (P value 0.05) which is statistically significant, 33.3% for floor of mouth, 15.4% for mandibular alveolus, 16.7% for retromolar trigon, and 35% for tongue. Oral SCC margin discrepancies after resection and specimen processing are highly significant. Margins shrinkage following resection and processing should be considered at the time of initial resection to prevent the discontent resulting from close or involved margins especially in low stage tumors. Tumors located in the buccal mucosa show significantly greater discrepancies than tumors of other sites

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