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Immunohistochemical expression of emmprin and morphometric analysis in adenoid cystic carcinoma / Hebatollah Khaled Mohamed Rizk ; Supervised Naglaa Mohamed Elhosary , Safa Fathy Abdelghani

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hebatollah Khaled Mohamed Rizk , 2014Description: 89 Leaves : facsimiles ; 30cmOther title:
  • {uFEED} {uFE8D}{uFEDF}{uFE97}{uFEA3}{uFEE0}{uFEF3}{uFEDD} {uFE8D}{uFEDF}{uFEE3}{uFEC5}{uFEEC}{uFEAD}ى {uئإؤ٣}ى {uئإ٨ؤ}{uئإؤئ}{uئإآ٣}{uئإءؤ}{uئإأ١}{uئإ٨إ}{uئإإ٥} {uئإ٨ؤ}{uئإؤئ}{uئإؤ٠}{uئإء٩}ى {uئإ٨ؤ}{uئإؤئ}{uئإؤآ}{uئإئ٣}{uئإآ٣}ى (EMMPRIN) {uFE8D}{uFEFB}{uFEE7}{uFE97}{uFEB7}{uFE8E}{uFEAD} {uFE8D}{uFEDF}{uFEE7}{uFEB3}{uFEF3}{uFE9F}{uFEF0} {uFE8D}{uFEDF}{uFEE3}{uFEE7}{uFE8E}{uFECB}{uFEF0} {uFE8D}{uFEDF}{uFEEC}{uFEB3}{uFE97}{uFEED}{uFEDB}{uFEF3}{uFEE3}{uFEF3}{uFE8E}{uFE8B}{uFEF0} {uFEDF}{uFEFA}{uFEE3}{uFE91}{uFEAD}{uFEF3}ن [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Pathology Summary: Adenoid cystic carcinoma (ACC) is one of the most common malignant tumors of salivary glands that often presents a diagnostic and treatment challenge. Our study aimed at understanding the biological behavior of this neoplasm through comparing the expression of the recent invasion molecular marker; extracellular matrix metalloproteinase inducer (EMMPRIN), as well as the cellular morphometric parameters (cellular area "CA", nuclear area "NA" and nuclear / cytoplasmic ratio "N / C ratio") among the 3 main histologic subtypes of ACC. The EMMPRIN expression area percent, as well as the morphometric parameters (CA, NA and N / C ratio) were measured and calculated in a total of 30 ACC specimens, roughly classified into ten cases having a predominating cribriform pattern, ten with tubular pattern, and ten with a solid pattern. EMMPRIN immunostaining as well as the CA, NA, and N / C ratio increased from the tubular group to the cribriform group, until reaching their highest values in the solid group. However, the statistical results of the morphometric analysis were non - significant. EMMPRIN expression seems to be related to the histopathological pattern of ACC, suggesting that it might help in the future grading of this salivary gland malignancy
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.09.04.M.Sc.2014.He.I (Browse shelf(Opens below)) Not for loan 01010110065488000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.09.04.M.Sc.2014.He.I (Browse shelf(Opens below)) 65488.CD Not for loan 01020110065488000

Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Pathology

Adenoid cystic carcinoma (ACC) is one of the most common malignant tumors of salivary glands that often presents a diagnostic and treatment challenge. Our study aimed at understanding the biological behavior of this neoplasm through comparing the expression of the recent invasion molecular marker; extracellular matrix metalloproteinase inducer (EMMPRIN), as well as the cellular morphometric parameters (cellular area "CA", nuclear area "NA" and nuclear / cytoplasmic ratio "N / C ratio") among the 3 main histologic subtypes of ACC. The EMMPRIN expression area percent, as well as the morphometric parameters (CA, NA and N / C ratio) were measured and calculated in a total of 30 ACC specimens, roughly classified into ten cases having a predominating cribriform pattern, ten with tubular pattern, and ten with a solid pattern. EMMPRIN immunostaining as well as the CA, NA, and N / C ratio increased from the tubular group to the cribriform group, until reaching their highest values in the solid group. However, the statistical results of the morphometric analysis were non - significant. EMMPRIN expression seems to be related to the histopathological pattern of ACC, suggesting that it might help in the future grading of this salivary gland malignancy

Issued also as CD

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