header
Local cover image
Local cover image
Image from OpenLibrary

The role of dexmedetomidine in decreasing acute kidney injury in children with acyanotic heart disease undergoing total correction by a new urinary biomarker kidney injury molecule-1 / Sarah Abdelsalam Elmetwally Kasem ; Supervised Azza Mohamed Ezzat , Wafaa Mohamed Alsadek , Olfat Gamil Shaker

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Sarah Abdelsalam Elmetwally Kasem , 2014Description: 132 Leaves : charts , facsimiles ; 25cmOther title:
  • دور عقار الدكسميدتوميدين في تقليل الإصابة الكلوية الحادة عند الأطفال المصابين بأمراض القلب اللازرقية الذين يخضعون للتصحيح الكامل بإستخدام الدلالة البولية الحديثة "كيم -1" [Added title page title]
Subject(s): Online resources: Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia Summary: Cardiac surgery with cardiopulmonary bypass (CPB) is the most frequent major surgical procedure worldwide. Acute kidney injury (AKI) is a common and serious complication encountered in 30{u2013}40% after CPB. Once AKI is established, there is no effective treatment for human AKI, and dialysis merely provides supportive care. There in lies the Achilles{u2019} heel of AKI management ; the paucity of early biomarkers has lead to an unacceptable delay in initiating therapy in humans.Serum creatinine is insensitive for the early detection of AKI. KIM-1 is one of the most highly induced proteins in the kidney after AKI in animal models, and a proteolytically processed domain of KIM-1 is easily detected in the urine soon after AKI. In a small human cross-sectional study, KIM-1 expression was markedly induced in proximal tubules in kidney biopsies from patients with established AKI (primarily ischemic), and urinary KIM-1 measured by ELISA distinguished ischemic AKI from prerenal azotemia and chronic renal disease
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.01.Ph.D.2014.Sa.R (Browse shelf(Opens below)) Not for loan 01010110065354000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.01.Ph.D.2014.Sa.R (Browse shelf(Opens below)) 65354.CD Not for loan 01020110065354000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia

Cardiac surgery with cardiopulmonary bypass (CPB) is the most frequent major surgical procedure worldwide. Acute kidney injury (AKI) is a common and serious complication encountered in 30{u2013}40% after CPB. Once AKI is established, there is no effective treatment for human AKI, and dialysis merely provides supportive care. There in lies the Achilles{u2019} heel of AKI management ; the paucity of early biomarkers has lead to an unacceptable delay in initiating therapy in humans.Serum creatinine is insensitive for the early detection of AKI. KIM-1 is one of the most highly induced proteins in the kidney after AKI in animal models, and a proteolytically processed domain of KIM-1 is easily detected in the urine soon after AKI. In a small human cross-sectional study, KIM-1 expression was markedly induced in proximal tubules in kidney biopsies from patients with established AKI (primarily ischemic), and urinary KIM-1 measured by ELISA distinguished ischemic AKI from prerenal azotemia and chronic renal disease

Issued also as CD

There are no comments on this title.

to post a comment.

Click on an image to view it in the image viewer

Local cover image