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Leukemic cell / microenvironment cross talk in acute myeloid leukemia : Effect on Cxcl12 level / Mai Farag Abdelkhalek Kelany ; Supervised Iman Maher Mansour , Rania Mohamed Samy , Hanan Alhusseini Mohamed

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Mai Farag Abdelkhalek Kelany , 2014Description: 58 P. : charts , facsimiles ; 25cmOther title:
  • الحوار المتبادل بين الخلايا السرطانية و البيئة الخلوية الدقيقة في حاالت سرطان الدم الميلودي وتأثيره على مستوى سي اكس سي ال [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology Summary: In the marrow microenvironment, acute leukemia cells are in close contact with marrow stromal cells. Mesenchymal stem cells (MSCs) secrete an array of signaling molecules. Among these factors is the chemokine CXCL12 (SDF-1), whose fine-tuned concentrations in the bone marrow are critical for maintaining the quiescence, survival and repopulation of hematopoeitic stem cell and leukemic cells through its main receptor, CXCR4. This study aimed to demonstrate the effect of leukemic cells on mesenchymal stromal cell production of CXCL12 through measuring BM plasma level of CXCL12 in addition to estimate the expression of its gene in MSCs. This study included 20 AML cases and 10 non neoplastic bone marrows as a control group
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Ma.L (Browse shelf(Opens below)) Not for loan 01010110065377000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.07.M.Sc.2014.Ma.L (Browse shelf(Opens below)) 65377.CD Not for loan 01020110065377000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology

In the marrow microenvironment, acute leukemia cells are in close contact with marrow stromal cells. Mesenchymal stem cells (MSCs) secrete an array of signaling molecules. Among these factors is the chemokine CXCL12 (SDF-1), whose fine-tuned concentrations in the bone marrow are critical for maintaining the quiescence, survival and repopulation of hematopoeitic stem cell and leukemic cells through its main receptor, CXCR4. This study aimed to demonstrate the effect of leukemic cells on mesenchymal stromal cell production of CXCL12 through measuring BM plasma level of CXCL12 in addition to estimate the expression of its gene in MSCs. This study included 20 AML cases and 10 non neoplastic bone marrows as a control group

Issued also as CD

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