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Structural and androgen receptors changes around the age of puberty in albino rat testis : A histological and immunohistochemical study / Reem Abdelaziz Abousehly ; Supervised Nabela Adeb Abdelmeseeh , Ehab Abdelaziz Ahmed , Ahmed Fouad Aldomairy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Reem Abdelaziz Abousehly , 2014Description: 127 P. : charts , facsimiles ; 25cmOther title:
  • التغيرات في التركيب ومستقبلات الأندروجين في مرحلة ما حول البلوغ في خصية الفأر الأبيض : دراسة هستولوجية وهيستوكيميائية مناعية [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Anatomy Summary: The peri-pubertal changes of Androgen receptors (AR) on Sertoli, Leydig and germ cells were monitored in the Albino rat (Sprague Dawley). Forty Five rats were used and sub grouped into 3 groups 15 rats each (pre-pubertal, pubertal and post-pubertal). The collected data manifest that AR play a critical role in male fertility since rat lacking AR showed incomplete germ cell proliferation and lowered testosterone level resulting in azoospermia and infertility. Germ cells Androgen receptors are not essential for spermatogenesis and normal fertility of rat. Androgens and AR signaling in Sertoli cells play the most important role in spermatogenesis. Androgen and AR signaling in Leydig cells display autocrine regulation. Lack of functioning AR of Leydig cells exert a major influence on Leydig cell steroidogenic function leading to arrest of spermatogenesis predominately during the spermatid stage
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.02.M.Sc.2014.Re.S (Browse shelf(Opens below)) Not for loan 01010110065579000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.02.M.Sc.2014.Re.S (Browse shelf(Opens below)) 65579.CD Not for loan 01020110065579000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Anatomy

The peri-pubertal changes of Androgen receptors (AR) on Sertoli, Leydig and germ cells were monitored in the Albino rat (Sprague Dawley). Forty Five rats were used and sub grouped into 3 groups 15 rats each (pre-pubertal, pubertal and post-pubertal). The collected data manifest that AR play a critical role in male fertility since rat lacking AR showed incomplete germ cell proliferation and lowered testosterone level resulting in azoospermia and infertility. Germ cells Androgen receptors are not essential for spermatogenesis and normal fertility of rat. Androgens and AR signaling in Sertoli cells play the most important role in spermatogenesis. Androgen and AR signaling in Leydig cells display autocrine regulation. Lack of functioning AR of Leydig cells exert a major influence on Leydig cell steroidogenic function leading to arrest of spermatogenesis predominately during the spermatid stage

Issued also as CD

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