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Anti - beta 2 glycoprotein I antibodies isotypes in systemic lupus erythematosus patients : Correlation with clinical and laboratory disease manifestations and manifestations of anti - phospholipid syndrome / Doaa Hassan Sayed Attia ; Supervised Azza Hussein Ali Elawar , Magda Ibrahim Mohamed Ayoub , Tamer Mohamed Atef Gheita

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Doaa Hassan Sayed Attia , 2014Description: 218 P. : facsimiles ; 25cmOther title:
  • الأنواع المتشابهة للأجسام المضادة لبيتا ٢ جليكوبروتين١ فى مرضى الذئبة الحمراء و علاقتها بالأعراض الإكلينيكية و المعملية للمرض و بأعراض متلازمة مضادات الدهون الفسفورية [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to components of the cell nucleus. The term antiphospholipid syndrome (APS) refers to a characteristic antibody - mediated thrombophilia; thrombotic events and pregnancy morbidity. The diagnosis of APS should be made on the presence of the characteristic clinical manifestations in association with persistently positive anticardiolipin / aCL IgM or IgG, anti - ß2glycoprotein I / anti - Ý2GPI IgM or IgG or lupus anticoagulant (LA). Antiphospholipid antibodies of immnnolglobulin A isotype were excluded from APS classification criteria based on lacking specificity and providing no additional information. Moreover, they are not fully standardized. Furthermore, there is a considerable difference among the studied ethnicities. Most of the studies supporting the usefulness of IgA aPL are of different designs. In addition their benefit could not be verified because they are commonly found in association with other antibodies
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Item type Current library Home library Call number Copy number Status Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.32.Ph.D.2014.Do.A (Browse shelf(Opens below)) Not for loan 01010110065647000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.32.Ph.D.2014.Do.A (Browse shelf(Opens below)) 65647.CD Not for loan 01020110065647000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies to components of the cell nucleus. The term antiphospholipid syndrome (APS) refers to a characteristic antibody - mediated thrombophilia; thrombotic events and pregnancy morbidity. The diagnosis of APS should be made on the presence of the characteristic clinical manifestations in association with persistently positive anticardiolipin / aCL IgM or IgG, anti - ß2glycoprotein I / anti - Ý2GPI IgM or IgG or lupus anticoagulant (LA). Antiphospholipid antibodies of immnnolglobulin A isotype were excluded from APS classification criteria based on lacking specificity and providing no additional information. Moreover, they are not fully standardized. Furthermore, there is a considerable difference among the studied ethnicities. Most of the studies supporting the usefulness of IgA aPL are of different designs. In addition their benefit could not be verified because they are commonly found in association with other antibodies

Issued also as CD

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