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Biophysical studies of melanin nanoparticles as radioprotectors / Doaa Galal Amin Mahmoud ; Supervised Reem Elgebaly , Monira Rageh , Hoda Abo-Shady

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Doaa Galal Amin Mahmoud , 2014Description: 74 P. : charts ; 25cmOther title:
  • دراسات بيوفيزيائية للميلانين المحضر بتكنولوجيا النانو كماده حاميه من الإشعاع [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics Summary: During radiotherapy, ionizing irradiation interacts with biological systems to produce free radicals, which attack various cellular components. The hematopoietic system is easily recognized to be radiosensitive and its damage may be severe. Melanin nanoparticles (MNPs) act as free radical scavengers prepared by polymerization of dopamine. In this study a total of 110 male BALB/C mice were divided into five equal groups. Each group contained 22 mice. Mice of group A did not receive MNPs or irradiation (control group), group B was injected intraperitoneally (i.p.) with 50 mg/kg MNPs. Mice of group C and D were exposed to a dose of 7 Gy {u0263}-irradiation and injected with the same dose of MNPs as in group B either 30 min pre- or post-irradiation, and group E was exposed to a dose of 7 Gy {u0263}-irradiation only. The impact of MNPs on peripheral blood, spleen and DNA damage induced by irradiation was evaluated by blood count, histopathology of the spleen and comet assay for the DNA in the bone marrow at 1, 4, 8 and 12 days post-irradiation
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.04.M.Sc.2014.Do.B (Browse shelf(Opens below)) Not for loan 01010110065746000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.04.M.Sc.2014.Do.B (Browse shelf(Opens below)) 65746.CD Not for loan 01020110065746000

Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biophysics

During radiotherapy, ionizing irradiation interacts with biological systems to produce free radicals, which attack various cellular components. The hematopoietic system is easily recognized to be radiosensitive and its damage may be severe. Melanin nanoparticles (MNPs) act as free radical scavengers prepared by polymerization of dopamine. In this study a total of 110 male BALB/C mice were divided into five equal groups. Each group contained 22 mice. Mice of group A did not receive MNPs or irradiation (control group), group B was injected intraperitoneally (i.p.) with 50 mg/kg MNPs. Mice of group C and D were exposed to a dose of 7 Gy {u0263}-irradiation and injected with the same dose of MNPs as in group B either 30 min pre- or post-irradiation, and group E was exposed to a dose of 7 Gy {u0263}-irradiation only. The impact of MNPs on peripheral blood, spleen and DNA damage induced by irradiation was evaluated by blood count, histopathology of the spleen and comet assay for the DNA in the bone marrow at 1, 4, 8 and 12 days post-irradiation

Issued also as CD

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