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The effect of Ivabradine on the clinical outcome and ventricular function in patients with chronic obstructive pulmonary disease / Kareem Mahmoud Abdelhamid Oransa ; Supervised Hossam Kandil , Youssry Akl , Essam Baligh

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Kareem Mahmoud Abdelhamid Oransa , 2014Description: 172 P. : charts ; 25cmOther title:
  • تأثير الايفابرادين على النتيجة السريرية و الوظيفة البطينية فى مرضى انسداد الشعب الهوائية المزمن [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Cardiology Summary: Diastolic dysfunction (DD) is common in COPD patients and can be responsible for worsening of functional capacity. Increased sympathetic tone secondary to hypoxia as well as the use of bronchodilators can accelerate heart rate leading to increased severity of DD leading to aggravation of symptoms and worsening of functional capacity. To study the short term effect of heart rate lowering drug ivabradine on clinical status and exercise capacity in COPD patients. COPD patients with sinus heart rate {u2265} 90 beats/min who were receiving inhaled bronchodilators± inhaled corticosteroids were included in the study. All patients with objective evidence of coronary artery disease, uncontrolled hypertension, left ventricular systolic dysfunction, left ventricular hypertrophy, significant valvular heart disease, significant tachyarrhythmia or bradyarrhythmia or unable to sign informed consent were excluded. All included patients were subjected to complete history and clinical examination including subjective assessment of dyspnea using modified Borg scale, electrocardiogram, chest X - ray, transthoracic echocardiogram, pulmonary function tests (PFT) and six minute walk distance 6MWD
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.04.Ph.D.2014.Ka.E (Browse shelf(Opens below)) Not for loan 01010110065686000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.04.Ph.D.2014.Ka.E (Browse shelf(Opens below)) 65686.CD Not for loan 01020110065686000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Cardiology

Diastolic dysfunction (DD) is common in COPD patients and can be responsible for worsening of functional capacity. Increased sympathetic tone secondary to hypoxia as well as the use of bronchodilators can accelerate heart rate leading to increased severity of DD leading to aggravation of symptoms and worsening of functional capacity. To study the short term effect of heart rate lowering drug ivabradine on clinical status and exercise capacity in COPD patients. COPD patients with sinus heart rate {u2265} 90 beats/min who were receiving inhaled bronchodilators± inhaled corticosteroids were included in the study. All patients with objective evidence of coronary artery disease, uncontrolled hypertension, left ventricular systolic dysfunction, left ventricular hypertrophy, significant valvular heart disease, significant tachyarrhythmia or bradyarrhythmia or unable to sign informed consent were excluded. All included patients were subjected to complete history and clinical examination including subjective assessment of dyspnea using modified Borg scale, electrocardiogram, chest X - ray, transthoracic echocardiogram, pulmonary function tests (PFT) and six minute walk distance 6MWD

Issued also as CD

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