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The role of cyclooxygenase - 2 and its metabolites (prostaglandin E2 and prostaglandin F2Ü) in the pathogenesis of tumor associated cachexia / Khaled Abdelmonem Elfady ; Supervised Dawlat A. Salem , Yasser H. Nassar , Hosni Khairy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Khaled Abdelmonem Elfady , 2014Description: 92 P. ; 25cmOther title:
  • دور السيكلواوكسيجينيز و نواتج أيضه (بروستاجلاندين إى٢ و بروستاجلاندين إف٢ ألفا) فى كيفية حدوث الهزال المصاحب لمرض السرطان [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry Summary: In recent years cyclooxygenase 2 (COX - 2) inhibitors have been increasingly investigated for their potential to inhibit growth of solid tumors. COX-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins, induced by in{uFB02}ammation and may play a role in the development of bladder cancer. Prostaglandin E2 (PGE2), the end product of COX - 2 - induced catalysis, autoamplifies the COX - 2 expression in solid tumors. It down regulates the apoptotic cascade PGE2 expression and COX - 2 activity is associated with cancer cachexia and tumorangiogenesis. The prominent clinical feature of cachexia is weight loss in adults or growth failure in children, anorexia, inflammation, insulin resistance, and increase muscle protein breakdown. The present work aims to clarify the pathogenesis of cachexia syndrome in cancer bladder patients and role may be played by cyclooxygenase 2 (COX2) and its metabolites prostaglandin E2 and PGF2Ü in occurrence of cachexia
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.03.M.Sc.2014.Kh.R (Browse shelf(Opens below)) Not for loan 01010110065692000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.03.M.Sc.2014.Kh.R (Browse shelf(Opens below)) 65692.CD Not for loan 01020110065692000

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry

In recent years cyclooxygenase 2 (COX - 2) inhibitors have been increasingly investigated for their potential to inhibit growth of solid tumors. COX-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins, induced by in{uFB02}ammation and may play a role in the development of bladder cancer. Prostaglandin E2 (PGE2), the end product of COX - 2 - induced catalysis, autoamplifies the COX - 2 expression in solid tumors. It down regulates the apoptotic cascade PGE2 expression and COX - 2 activity is associated with cancer cachexia and tumorangiogenesis. The prominent clinical feature of cachexia is weight loss in adults or growth failure in children, anorexia, inflammation, insulin resistance, and increase muscle protein breakdown. The present work aims to clarify the pathogenesis of cachexia syndrome in cancer bladder patients and role may be played by cyclooxygenase 2 (COX2) and its metabolites prostaglandin E2 and PGF2Ü in occurrence of cachexia

Issued also as CD

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