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The Impact of BRCA1, BRCA2 genes and MMTV in Familial and non-familial Breast Cancer / Zeinab Fathy Abdallah Elkalinne ; Supervised Abdelrahman Nabawy Zekri , Mohamed Shaalan , Samah Aly Loutfy

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Zeinab Fathy Abdallah Elkalinne , 2014Description: 201 P. : charts , facsimiles ; 25cmOther title:
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Dissertation note: Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology Summary: Background: Viruses are considered to be an important risk factors closely related to human breast cancer. The involvement of a retrovirus homologous to the mouse mammary tumor virus (MMTV) in the pathogenesis of human breast cancer (BC) has long been assumed, but has never been proven. Germline mutations of the BRCA1 and BRCA2 genes are the most significant and well-characterized genetic risk factors for breast and/or ovarian cancer to date. The frequency and range of mutations in a specific ethnic population provides important factor in genetic counseling and cancer risk assessment. Aim of the work: To explore the frequency of MMTV-like sequences and BRCA genes mutations in familial and non- familial Egyptian breast cancer patients, to investigate the possible association between the infection by MMTV and BRCA genes mutations, and to assess the impact of other well-known risk factors in worsening outcome of breast cancer disease.
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.02.Ph.D.2014.Ze.I (Browse shelf(Opens below)) Not for loan 01010110065882000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.19.02.Ph.D.2014.Ze.I (Browse shelf(Opens below)) 65882.CD Not for loan 01020110065882000

Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Cancer Biology

Background: Viruses are considered to be an important risk factors closely related to human breast cancer. The involvement of a retrovirus homologous to the mouse mammary tumor virus (MMTV) in the pathogenesis of human breast cancer (BC) has long been assumed, but has never been proven. Germline mutations of the BRCA1 and BRCA2 genes are the most significant and well-characterized genetic risk factors for breast and/or ovarian cancer to date. The frequency and range of mutations in a specific ethnic population provides important factor in genetic counseling and cancer risk assessment. Aim of the work: To explore the frequency of MMTV-like sequences and BRCA genes mutations in familial and non- familial Egyptian breast cancer patients, to investigate the possible association between the infection by MMTV and BRCA genes mutations, and to assess the impact of other well-known risk factors in worsening outcome of breast cancer disease.

Issued also as CD

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