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Study of the possible hepatoprotective mechanisms of coenzyme Q10 in experimentally induced hepatotoxicty in rats / Passant Elwy Moustafa ; Supervised Sanaa A. Kenawy , Osama A. Elshabrawy , Hala F. Zaki

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Passant Elwy Moustafa , 2014Description: 202 P. : charts , facsimiles ; 25cmOther title:
  • فى تسمم الكبد المحدث تجريبيا فى الجرذان Q10 دراسة الاليات المحتملة لحماية الكبد بواسطة الإنزيم المتمم [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Paracetamol and diclofenac are commonly used analgesics, result in serious adverse outcomes including hepatotoxicity. The potential hepatoprotective effect of coenzyme Q10 (CoQ10) and nifedipine was investigated in rats against acute hepatic injury induced by paracetamol (600 mg/kg) or diclofenac (100 mg/kg). Animals were classified into 9 groups (n = 8). The 1st group recived 1% tween 80 and served as normal. Group 2 received paracetamol (600 mg/kg) on the seventh day. Group 3 received diclofenac (100 mg/kg) on the 7th and 8th day. Three groups received silymarin (50 mg/kg) as a reference standard, nifedipine (10 mg/kg) or CoQ10 (10 mg/kg) for 7 days and paracetamol 600 (mg /kg) on the 7th day. The remaining 3 groups were received the test drugs for 8 days and diclofenac (100 mg/kg) on the 7th and 8th day
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2014.Pa.S (Browse shelf(Opens below)) Not for loan 01010110065812000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2014.Pa.S (Browse shelf(Opens below)) 65812.CD Not for loan 01020110065812000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Paracetamol and diclofenac are commonly used analgesics, result in serious adverse outcomes including hepatotoxicity. The potential hepatoprotective effect of coenzyme Q10 (CoQ10) and nifedipine was investigated in rats against acute hepatic injury induced by paracetamol (600 mg/kg) or diclofenac (100 mg/kg). Animals were classified into 9 groups (n = 8). The 1st group recived 1% tween 80 and served as normal. Group 2 received paracetamol (600 mg/kg) on the seventh day. Group 3 received diclofenac (100 mg/kg) on the 7th and 8th day. Three groups received silymarin (50 mg/kg) as a reference standard, nifedipine (10 mg/kg) or CoQ10 (10 mg/kg) for 7 days and paracetamol 600 (mg /kg) on the 7th day. The remaining 3 groups were received the test drugs for 8 days and diclofenac (100 mg/kg) on the 7th and 8th day

Issued also as CD

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