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Pharmaceutical study on certain ocular drug delivery systems / Osama Saher Abdelmonem ; Supervised . Nadia Mohamed Mursi , Dalia Mahmoud Ghorab

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Osama Saher Abdelmonem , 2014Description: 193 P. : facsimiles ; 25cmOther title:
  • دراسة صيدلية على بعض أنظمة توصيل العقار للعين [Added title page title]
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  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: In this thesis, the researcher aimed to formulate ocular sustained drug delivery systems of levofloxacin hemihydrate that combined controlling the release of the drug and decreasing the need to recurrent application thus increasing the patient compliance. In order to achieve this goal, the work in this research was divided into three chapters Chapter I: Formulation and In Vitro Evaluation of levofloxacin hemihydrate in situ gels. Chapter II: Formulation and In Vitro Evaluation of levofloxacin hemihydrate hemi-sponges. Chapter III: Microbiological susceptibility and eye irritation tests of different levofloxacin hemihydrate formulae. From these chapters, we were able to prepare and test two different sustained release ocular dosage forms (in situ gels containing our freshly prepared disappearing preservative and hemi-sponges) that can be applied twice daily instead of 8 times daily in Egyptian market used eye drops. Our prepared formulae proved to be safer (using lower number of doses), cheaper, having prolonged release for 12 hrs and they would be expected to have higher levels of patient compliance making them a promising candidate for topically applied antimicrobials for eye infections
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2014.Os.P (Browse shelf(Opens below)) Not for loan 01010110065819000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.08.M.Sc.2014.Os.P (Browse shelf(Opens below)) 65819.CD Not for loan 01020110065819000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

In this thesis, the researcher aimed to formulate ocular sustained drug delivery systems of levofloxacin hemihydrate that combined controlling the release of the drug and decreasing the need to recurrent application thus increasing the patient compliance. In order to achieve this goal, the work in this research was divided into three chapters Chapter I: Formulation and In Vitro Evaluation of levofloxacin hemihydrate in situ gels. Chapter II: Formulation and In Vitro Evaluation of levofloxacin hemihydrate hemi-sponges. Chapter III: Microbiological susceptibility and eye irritation tests of different levofloxacin hemihydrate formulae. From these chapters, we were able to prepare and test two different sustained release ocular dosage forms (in situ gels containing our freshly prepared disappearing preservative and hemi-sponges) that can be applied twice daily instead of 8 times daily in Egyptian market used eye drops. Our prepared formulae proved to be safer (using lower number of doses), cheaper, having prolonged release for 12 hrs and they would be expected to have higher levels of patient compliance making them a promising candidate for topically applied antimicrobials for eye infections

Issued also as CD

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