Formulation and evaluation of antibiotic nano- systems for treatment of ocular infections / Carol Yousry Ghattas ; Supervised Seham A. Elkheshen , Hanan M. Ellaithy , Rania Hasan Fahmy

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Carol Yousry Ghattas

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TextLanguage: English Publication details: Cairo : Carol Yousry Ghattas , 2014Description: 218 P. : charts , facsimiles ; 25cmOther title:

صياغة وتقييم أنظمة نانومترية حاملة لمضاد حيوى لعلاج التهابات العين [Added title page title]

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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics Summary: In Egypt, due to the high rate of pollution, ocular infections are considered one of the main threatening problems that affect the Egyptian community. In order to encounter this problem, a microbiologic multi- district survey was conducted to detect the most prevalent causative agent of ocular infections in Egypt. Further, an antibiotic- sensitivity testing was applied to the isolated microorganism where Vancomycinwas found to be the most potent agent. The aim of the work in this thesis was to enhance local bioavailability of Vancomycin (VCM) by enhancing its ocular residence and possibly increase its corneal permeability. VCM- loaded SLNs were prepared by double emulsion (W/O/W) solvent evaporation technique. Two factorial designs were adopted to study the effect of different process and formulation variables as well as the effect of lipid on the formulated nanoparticles. The optimization of the results revealed that F6.3 is the optimum formula which was composed of GTP in lipid: drug ratio 1:1, 1% low molecular weight PVA and by applying 1 minute sonication time. In addition, DSC, FTIR, SEM and TEM were applied for further characterization of the optimized formula

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Holdings
Item type	Current library	Home library	Call number	Copy number	Status	Date due	Barcode
Thesis	قاعة الرسائل الجامعية - الدور الاول	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.08.08.M.Sc.2014.Ca.F (Browse shelf(Opens below))		Not for loan		01010110065932000
CD - Rom	مخـــزن الرســائل الجـــامعية - البدروم	المكتبة المركزبة الجديدة - جامعة القاهرة	Cai01.08.08.M.Sc.2014.Ca.F (Browse shelf(Opens below))	65932.CD	Not for loan		01020110065932000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics

In Egypt, due to the high rate of pollution, ocular infections are considered one of the main threatening problems that affect the Egyptian community. In order to encounter this problem, a microbiologic multi- district survey was conducted to detect the most prevalent causative agent of ocular infections in Egypt. Further, an antibiotic- sensitivity testing was applied to the isolated microorganism where Vancomycinwas found to be the most potent agent. The aim of the work in this thesis was to enhance local bioavailability of Vancomycin (VCM) by enhancing its ocular residence and possibly increase its corneal permeability. VCM- loaded SLNs were prepared by double emulsion (W/O/W) solvent evaporation technique. Two factorial designs were adopted to study the effect of different process and formulation variables as well as the effect of lipid on the formulated nanoparticles. The optimization of the results revealed that F6.3 is the optimum formula which was composed of GTP in lipid: drug ratio 1:1, 1% low molecular weight PVA and by applying 1 minute sonication time. In addition, DSC, FTIR, SEM and TEM were applied for further characterization of the optimized formula

Issued also as CD

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