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Management of the possible hepatotoxic effect of concomitant use of tramadol and alcohol by some antioxidants in rats / Shimaa Mohamed Azmy Mohamed ; Supervised Ezz Eldin Said Eldenshary , Somaia Ahmed Nada

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Shimaa Mohamed Azmy Mohamed , 2014Description: 154 P. : charts , photographs ; 25cmOther title:
  • معالجة التسمم الكبدى الذى قد ينتج عن الإعطاء المتزامن لدواء ترامادول مع الكحول باستخدام بعض مضادات الأكسدة فى الجرذان [Added title page title]
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Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: The combination of tramadol and alcohol caused threatening or fatal side effects. The aim of present study was to investigate the effect of ethanol, tramadol and there combination on rat liver{u037E} and the role of grape seed extract (GSE) and silymarin as natural hepatoprotective agents versus ethanol-tramadol combination. Ten equal groups (8 rats each) were treated as follows: Group 1 kept as control group orally given 10ml / Kg, distilled water{u037E} Groups 2, 3 and 4 treated with combination of ethanol (3.7g / Kg, P.O.) and tramadol (20 mg / kg, i.p.), tramadol (20 mg / kg) and alcohol (3.7g / kg), respectively. Groups 5 and 6 given GSE (150 mg / kg) in concomitant with tramadol and alcohol or with silymarin (100 mg / kg), respectively. Groups 7 and 8 administered GSE or silymarin concomitant with tramadol. Groups 9 and 10 orally treated with GSE or silymarin concomitant with alcohol
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Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2014.Sh.M (Browse shelf(Opens below)) Not for loan 01010110066024000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2014.Sh.M (Browse shelf(Opens below)) 66024.CD Not for loan 01020110066024000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

The combination of tramadol and alcohol caused threatening or fatal side effects. The aim of present study was to investigate the effect of ethanol, tramadol and there combination on rat liver{u037E} and the role of grape seed extract (GSE) and silymarin as natural hepatoprotective agents versus ethanol-tramadol combination. Ten equal groups (8 rats each) were treated as follows: Group 1 kept as control group orally given 10ml / Kg, distilled water{u037E} Groups 2, 3 and 4 treated with combination of ethanol (3.7g / Kg, P.O.) and tramadol (20 mg / kg, i.p.), tramadol (20 mg / kg) and alcohol (3.7g / kg), respectively. Groups 5 and 6 given GSE (150 mg / kg) in concomitant with tramadol and alcohol or with silymarin (100 mg / kg), respectively. Groups 7 and 8 administered GSE or silymarin concomitant with tramadol. Groups 9 and 10 orally treated with GSE or silymarin concomitant with alcohol

Issued also as CD

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